Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.600 Therapeutic RGD We found that NP03 rescued key initiating components of AD pathology, including inactivating GSK-3β, reducing BACE1 expression and activity, and reducing amyloid levels. 28763060

2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.580 Biomarker MGD Collectively, our findings suggest that alterations in BACE1-dependent NRG1/ErbB4 signaling may participate in the pathogenesis of schizophrenia and related psychiatric disorders. 18385378

2008
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.580 Biomarker MGD BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis, is essential for cognitive, emotional, and synaptic functions. 16354928

2005
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0338656
Disease: Impaired cognition
Impaired cognition 		0.300 Biomarker RGD Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aβ-related metabolism. 28455102

2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0240059
Disease: Ventricular hemorrhage
Ventricular hemorrhage 		0.200 Biomarker RGD The correlation between accumulation of amyloid beta with enhanced neuroinflammation and cognitive impairment after intraventricular hemorrhage. 30028260

2018
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.200 Biomarker RGD miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation. 28012171

2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0037316
Disease: Sleep Deprivation
Sleep Deprivation 		0.200 Biomarker RGD Sleep deprivation accelerates the progression of alzheimer's disease by influencing Aβ-related metabolism. 28455102

2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0151313
Disease: Sensory neuropathy
Sensory neuropathy 		0.200 Biomarker RGD miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation. 28012171

2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0154319
Disease: Other specified senile psychotic conditions
Other specified senile psychotic conditions 		0.200 Therapeutic RGD MiR-9 Regulates the Expression of BACE1 in Dementia Induced by Chronic Brain Hypoperfusion in Rats. 28683457

2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0699739
Disease: Sensory Neuropathy, Hereditary
Sensory Neuropathy, Hereditary 		0.200 Biomarker RGD miR-15b mediates oxaliplatin-induced chronic neuropathic pain through BACE1 down-regulation. 28012171

2017
Entrez Id: 23621
Gene Symbol: BACE1
BACE1
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.200 Biomarker RGD Increased beta-secretase activity and expression in rats following transient cerebral ischemia. 15120577

2004