Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0920646
Disease: Ischemia of kidney
Ischemia of kidney 		0.200 Therapeutic RGD Apaf-1 inhibitors protect from unwanted cell death in in vivo models of kidney ischemia and chemotherapy induced ototoxicity. 25330150

2014
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.200 Therapeutic RGD Protective effect of flavonoid-rich extract from Rosa laevigata Michx on cerebral ischemia-reperfusion injury through suppression of apoptosis and inflammation. 24012531

2013
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.200 Therapeutic RGD Piroxicam and C-phycocyanin mediated apoptosis in 1,2-dimethylhydrazine dihydrochloride induced colon carcinogenesis: exploring the mitochondrial pathway. 22369161

2012
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0035126
Disease: Reperfusion Injury
Reperfusion Injury 		0.200 Biomarker RGD Propofol reduces nitric oxide-induced apoptosis in testicular ischemia-reperfusion injury by downregulating the expression of inducible nitric oxide synthase. 18205898

2008
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0007786
Disease: Brain Ischemia
Brain Ischemia 		0.200 Biomarker RGD Greater stress protein expression enhanced by combined prostaglandin A1 and lithium in a rat model of focal ischemia. 17640469

2007
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0026846
Disease: Muscular Atrophy
Muscular Atrophy 		0.200 Biomarker RGD Elevated caspase and AIF gene expression correlate with progression of sarcopenia during aging in male F344BN rats. 17029665

2006
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.200 Biomarker RGD Identification of the apoptosis activation cascade induced in mammary carcinomas by energy restriction. 14973070

2004
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0270824
Disease: Visual seizure
Visual seizure 		0.200 Biomarker RGD Formation of the Apaf-1/cytochrome c complex precedes activation of caspase-9 during seizure-induced neuronal death. 11753565

2001