Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker RGD High blood pressure effects on the blood to cerebrospinal fluid barrier and cerebrospinal fluid protein composition: a two-dimensional electrophoresis study in spontaneously hypertensive rats. 23401751

2013
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0027726
Disease: Nephrotic Syndrome
Nephrotic Syndrome 		0.340 Biomarker RGD Eight genes involved in cholesterol metabolism, Apo A-I, Acly, Acat, Mpd, Fdps, Ss, Lss, and Nsdhl, were significantly upregulated under NS. 18614621

2008
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0003850
Disease: Arteriosclerosis
Arteriosclerosis 		0.300 Therapeutic RGD By mediating reverse cholesterol transport and exerting antioxidant/anti-inflammatory actions, high-density lipoprotein (HDL) and ApoA-1 protect against atherosclerosis. 20639628

2010
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.300 Biomarker RGD Diversity of metabolic syndrome risk factors in obese children and adolescents. 17217166

2006
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0243026
Disease: Sepsis
Sepsis 		0.240 Therapeutic RGD Apolipoprotein A-I mimetic peptide treatment inhibits inflammatory responses and improves survival in septic rats. 19561306

2009
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.200 Therapeutic RGD HDL Mimetic Peptide Administration Improves Left Ventricular Filling and Cardiac output in Lipopolysaccharide-Treated Rats. 23227448

2011
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0024517
Disease: Major depression, single episode
Major depression, single episode 		0.200 SusceptibilityMutation RGD Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression. 20580919

2010
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0154409
Disease: Recurrent major depressive episodes
Recurrent major depressive episodes 		0.200 SusceptibilityMutation RGD Early-life stress and antidepressants modulate peripheral biomarkers in a gene-environment rat model of depression. 20580919

2010
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0007138
Disease: Carcinoma, Transitional Cell
Carcinoma, Transitional Cell 		0.200 Biomarker RGD Identification of differently expressed genes in chemical carcinogen-induced rat bladder cancers. 19399409

2009
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0334265
Disease: Transitional Cell Neoplasm
Transitional Cell Neoplasm 		0.200 Biomarker RGD Identification of differently expressed genes in chemical carcinogen-induced rat bladder cancers. 19399409

2009
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0028840
Disease: Ocular Hypertension
Ocular Hypertension 		0.200 Biomarker RGD Proteomic analysis of rat retina in a steroid-induced ocular hypertension model: potential vulnerability to oxidative stress. 18626730

2008
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Therapeutic RGD Long-term treatment with the apolipoprotein A1 mimetic peptide increases antioxidants and vascular repair in type I diabetic rats. 17488882

2007
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0020550
Disease: Hyperthyroidism
Hyperthyroidism 		0.200 Biomarker RGD Apo A-I gene expression is stimulated by thyroid hormone, whereas apo A-II mRNA abundance is decreased in chronic hyperthyroidism. 1466661

1992
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0020639
Disease: Hypoproteinemia
Hypoproteinemia 		0.200 Biomarker RGD Transcriptional and posttranscriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states. 2123716

1990
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.200 Biomarker RGD Transcriptional and posttranscriptional regulation of apolipoprotein E, A-I, and A-II gene expression in normal rat liver and during several pathophysiologic states. 2123716

1990
Entrez Id: 335
Gene Symbol: APOA1
APOA1
CUI: C0149940
Disease: Sciatic Neuropathy
Sciatic Neuropathy 		0.200 Biomarker RGD A role for apolipoprotein E, apolipoprotein A-I, and low density lipoprotein receptors in cholesterol transport during regeneration and remyelination of the rat sciatic nerve. 2493483

1989