Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0009404
Disease: Colorectal Neoplasms
Colorectal Neoplasms 		0.700 Therapeutic RGD Angiostatic properties of sulindac and celecoxib in the experimentally induced inflammatory colorectal cancer. 23149858

2013
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.700 Biomarker RGD Upregulation of tissue inhibitor of metalloproteases-1 (TIMP-1) and procollagen-N-peptidase in hypertension-induced renal damage. 17977875

2008
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.600 Biomarker RGD Together our results suggest that MMP-2, -3 and -9 may be involved in the process of metastasis of breast cancer to the brain. 16158251

2005
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker RGD ET(A)-receptor blockade prevents matrix metalloproteinase activation late postmyocardial infarction in the rat. 11179039

2001
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.600 Biomarker RGD Evolution of matrix metalloprotease and tissue inhibitor expression during heart failure progression in the infarcted rat. 10773235

2000
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0162872
Disease: Aortic Aneurysm, Thoracic
Aortic Aneurysm, Thoracic 		0.520 Biomarker RGD Elevation of ADAM10, ADAM17, MMP-2 and MMP-9 expression with media degeneration features CaCl2-induced thoracic aortic aneurysm in a rat model. 20621845

2010
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0085762
Disease: Alcohol abuse
Alcohol abuse 		0.510 Biomarker RGD These results suggest that MMP-2 and MMP-9 may play a significant role in blood-brain barrier disruption after alcohol abuse. 24966898

2014
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0023890
Disease: Liver Cirrhosis
Liver Cirrhosis 		0.510 Therapeutic RGD Pterostilbene inhibits dimethylnitrosamine-induced liver fibrosis in rats. 23411180

2013
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C2936380
Disease: Neointima
Neointima 		0.500 Therapeutic RGD Cariporide, a specific Na/H(+) exchanger 1 blocker, inhibits neointimal proliferation induced by advanced glycation end products in a balloon injury rat model. 23344254

2013
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0023904
Disease: Liver Neoplasms, Experimental
Liver Neoplasms, Experimental 		0.500 Biomarker RGD Morin regulates the expression of NF-kappaB-p65, COX-2 and matrix metalloproteinases in diethylnitrosamine induced rat hepatocellular carcinoma. 19539802

2009
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0023904
Disease: Liver Neoplasms, Experimental
Liver Neoplasms, Experimental 		0.500 Biomarker RGD Black tea polyphenols target matrix metalloproteinases, RECK, proangiogenic molecules and histone deacetylase in a rat hepatocarcinogenesis model. 19528495

2009
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0024668
Disease: Mammary Neoplasms, Experimental
Mammary Neoplasms, Experimental 		0.500 Biomarker RGD Evaluation of molecular markers in a rat model of mammary carcinogenesis. 19725228

2009
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0032460
Disease: Polycystic Ovary Syndrome
Polycystic Ovary Syndrome 		0.330 Biomarker RGD The levels of SLPI mRNA and protein expression were higher in PCO than in the normal ovary, and the level of MMP-2 expression was lower in PCO. 21910062

2011
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.300 Therapeutic RGD Antioxidant Vitamin C attenuates experimental abdominal aortic aneurysm development in an elastase-induced rat model. 24484904

2014
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.300 Therapeutic RGD Downregulation of remodelling enzymatic activity induced by an angiotensin-converting enzyme inhibitor (perindopril) reduces the degeneration of experimental abdominal aortic aneurysms in a rat model. 21256058

2011
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0014175
Disease: Endometriosis
Endometriosis 		0.300 Biomarker RGD Autologous peritoneal fluid stimulated MMP-2 mRNA expression in eutopic endometrium of women with endometriosis. 20056200

2010
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.300 Biomarker RGD Thrombus versus wall biological activities in experimental aortic aneurysms. 20016209

2010
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.300 Biomarker RGD Eugenol induces apoptosis and inhibits invasion and angiogenesis in a rat model of gastric carcinogenesis induced by MNNG. 20434464

2010
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0017638
Disease: Glioma
Glioma 		0.300 Therapeutic RGD Gamma-linolenic acid inhibits both tumour cell cycle progression and angiogenesis in the orthotopic C6 glioma model through changes in VEGF, Flt1, ERK1/2, MMP2, cyclin D1, pRb, p53 and p27 protein expression. 19292920

2009
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0004153
Disease: Atherosclerosis
Atherosclerosis 		0.300 Biomarker RGD Our results suggest that the expression of CD40 and CD40L in the blood cells and the activities of MMP-2 and MMP-9 in plasma were higher in As group than those in Normal group, indicating that they may contribute to the formation of atherosclerosis. 16317521

2006
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.300 Biomarker RGD Genetic kininogen deficiency contributes to aortic aneurysm formation but not to atherosclerosis. 15238617

2004
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0162871
Disease: Aortic Aneurysm, Abdominal
Aortic Aneurysm, Abdominal 		0.300 Biomarker RGD The objective of this study was to determine the significance of membrane type 1 matrix metalloproteinase (MT1-MMP) activation of MMP-2 in experimental abdominal aortic aneurysms. 15300177

2004
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0038454
Disease: Cerebrovascular accident
Cerebrovascular accident 		0.290 Biomarker RGD Increased intranuclear matrix metalloproteinase activity in neurons interferes with oxidative DNA repair in focal cerebral ischemia. 19840223

2010
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0031099
Disease: Periodontitis
Periodontitis 		0.290 Biomarker RGD MMP-2 and MMP-3 may play an important role in development of periodontitis. 16845949

2006
Entrez Id: 4313
Gene Symbol: MMP2
MMP2
CUI: C0018802
Disease: Congestive heart failure
Congestive heart failure 		0.290 Biomarker RGD MMP/TIMP expression in spontaneously hypertensive heart failure rats: the effect of ACE- and MMP-inhibition. 10773234

2000