Source: ORPHANET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0276496
Disease: Familial Alzheimer Disease (FAD)
Familial Alzheimer Disease (FAD) 		0.510 GeneticVariation ORPHANET TREM2 R47H variant as a risk factor for early-onset Alzheimer's disease. 23380991

2013
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0002736
Disease: Amyotrophic Lateral Sclerosis
Amyotrophic Lateral Sclerosis 		0.500 SusceptibilityMutation ORPHANET The TREM2 variant p.R47H was more common in patients with ALS than in the controls and is therefore a significant risk factor for ALS (odds ratio, 2.40; 95% CI, 1.29-4.15; P = 4.1×10-3). 24535663

2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0338462
Disease: Semantic Dementia
Semantic Dementia 		0.400 SusceptibilityMutation ORPHANET Heterozygous TREM2 mutations in frontotemporal dementia. 24139279

2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0338462
Disease: Semantic Dementia
Semantic Dementia 		0.400 SusceptibilityMutation ORPHANET Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes. 25042114

2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C4011788
Disease: Behavioral variant of frontotemporal dementia
Behavioral variant of frontotemporal dementia 		0.320 SusceptibilityMutation ORPHANET Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes. 25042114

2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C4011788
Disease: Behavioral variant of frontotemporal dementia
Behavioral variant of frontotemporal dementia 		0.320 SusceptibilityMutation ORPHANET Heterozygous TREM2 mutations in frontotemporal dementia. 24139279

2014
Entrez Id: 54209
Gene Symbol: TREM2
TREM2
CUI: C0751706
Disease: Primary Progressive Nonfluent Aphasia
Primary Progressive Nonfluent Aphasia 		0.300 SusceptibilityMutation ORPHANET Investigation of the role of rare TREM2 variants in frontotemporal dementia subtypes. 25042114

2014