Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0011570
Disease: Mental Depression
Mental Depression 		0.200 Therapeutic RGD Improved age-related deficits in cognitive performance and affective-like behavior following acute, but not repeated, 8-OH-DPAT treatments in rats: regulation of hippocampal FADD. 30138765

2018
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0752308
Disease: Hypoxia-Ischemia, Brain
Hypoxia-Ischemia, Brain 		0.200 Therapeutic RGD Edaravone attenuates neuronal apoptosis in hypoxic-ischemic brain damage rat model via suppression of TRAIL signaling pathway. 29635023

2018
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 Therapeutic RGD Anti-apoptotic and Pro-survival Effects of Food Restriction on High-Fat Diet-Induced Obese Hearts. 27131981

2017
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C3665419
Disease: intracranial glioma
intracranial glioma 		0.200 Therapeutic RGD T11TS Treatment Augments Apoptosis of Glioma Associated Brain Endothelial Cells, Hint Toward Anti-Angiogenic Action in Glioma. 27255231

2017
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0027055
Disease: Myocardial Reperfusion Injury
Myocardial Reperfusion Injury 		0.200 Therapeutic RGD Pretreatment with low-dose gadolinium chloride attenuates myocardial ischemia/reperfusion injury in rats. 26948086

2016
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C1739363
Disease: Prostatic Hypertrophy
Prostatic Hypertrophy 		0.200 Therapeutic RGD Rice Hull Extract Suppresses Benign Prostate Hyperplasia by Decreasing Inflammation and Regulating Cell Proliferation in Rats. 27441629

2016
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.200 Therapeutic RGD Anti-apoptotic effect of San Huang Shel Shin Tang cyclodextrin complex (SHSSTc) on CCl4 -induced hepatotoxicity in rats. 25447754

2016
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0392622
Disease: Toxic effect of carbon tetrachloride
Toxic effect of carbon tetrachloride 		0.200 Therapeutic RGD Anti-apoptosis effects on hearts of SHSST cyclodextrin complex in a carbon tetrachloride-induced cirrhotic cardiomyopathy rat model. 25687490

2015
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C4277682
Disease: Chemical and Drug Induced Liver Injury
Chemical and Drug Induced Liver Injury 		0.200 Therapeutic RGD Hepato-protective effect of rutin via IL-6/STAT3 pathway in CCl4-induced hepatotoxicity in rats. 26062544

2015
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.200 Therapeutic RGD Anti-apoptotic and pro-survival effect of protocatechuic acid on hypertensive hearts. 24355328

2014
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.200 Biomarker RGD Activated apoptotic and anti-survival effects on rat hearts with fructose induced metabolic syndrome. 23657904

2014
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.200 Therapeutic RGD Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats. 24122010

2013
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0740392
Disease: Infarction, Middle Cerebral Artery
Infarction, Middle Cerebral Artery 		0.200 Therapeutic RGD Effect of Danshen aqueous extract on serum hs-CRP, IL-8, IL-10, TNF-α levels, and IL-10 mRNA, TNF-α mRNA expression levels, cerebral TGF-β1 positive expression level and its neuroprotective mechanisms in CIR rats. 23378241

2013
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0026552
Disease: Morphine Dependence
Morphine Dependence 		0.200 ModifyingMutation RGD Correlation of rat cortical Fas-associated death domain (FADD) protein phosphorylation with the severity of spontaneous morphine abstinence syndrome: role of α(2)-adrenoceptors and extracellular signal-regulated kinases. 21088039

2011
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0028754
Disease: Obesity
Obesity 		0.200 Biomarker RGD The whole heart weight, the left ventricular weight, the abnormal myocardial architecture, and TUNEL-positive apoptotic cells, as well as the activity of cardiac Fas-dependent and mitochondrial-dependent apoptotic pathway, were significantly increased in obese group or nocturnal sustained hypoxia group and were further increased when obesity and nocturnal sustained hypoxia coexisted, the evidence for which is based on decreases in an anti-apoptotic protein Bcl2 level and Bid and increases in Fas, FADD, pro-apoptotic Bad, BNIP3, cytosolic cytochrome c, activated caspase-8, activated caspase-9, and activated caspase-3. 18202171

2008
Entrez Id: 8772
Gene Symbol: FADD
FADD
CUI: C0242706
Disease: Hyperoxia
Hyperoxia 		0.200 Biomarker RGD A critical role for Fas/CD-95 dependent signaling pathways in the pathogenesis of hyperoxia-induced brain injury. 19107989

2008