Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Therapeutic RGD Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats. 27847271

2017
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0020429
Disease: Hyperalgesia
Hyperalgesia 		0.500 Biomarker RGD Involvement of Charcot-Marie-Tooth disease gene mitofusin 2 expression in paclitaxel-induced mechanical allodynia in rats. 28587902

2017
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.500 Therapeutic RGD In this study, the molecular mechanisms for the effect of Mfn2 on mitochondria and subsequent collagen IV expression in DN were investigated. 27997345

2016
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0018800
Disease: Cardiomegaly
Cardiomegaly 		0.500 Biomarker RGD Candesartan cilexetil attenuated cardiac remodeling by improving expression and function of mitofusin 2 in SHR. 27085127

2016
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.500 Therapeutic RGD Activation of FoxO1/ PGC-1α prevents mitochondrial dysfunction and ameliorates mesangial cell injury in diabetic rats. 26123583

2015
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0021655
Disease: Insulin Resistance
Insulin Resistance 		0.300 Therapeutic RGD Swimming improves high-fat induced insulin resistance by regulating lipid and energy metabolism and the insulin pathway in rats. 24715199

2014
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.260 Biomarker RGD Swimming attenuates d-galactose-induced brain aging via suppressing miR-34a-mediated autophagy impairment and abnormal mitochondrial dynamics. 28302704

2017
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.240 Therapeutic RGD Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats. 27847271

2017
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease 		0.240 Biomarker RGD Mitofusin 2 ameliorates aortic remodeling by suppressing ras/raf/ERK pathway and regulating mitochondrial function in vascular smooth muscle cells. 25464244

2015
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0028754
Disease: Obesity
Obesity 		0.240 Biomarker RGD In utero exposure to prepregnancy maternal obesity and postweaning high-fat diet impair regulators of mitochondrial dynamics in rat placenta and offspring. 25336449

2014
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0243026
Disease: Sepsis
Sepsis 		0.220 Biomarker RGD Abnormal mitochondrial fusion-fission balance contributes to the progression of experimental sepsis. 24720571

2014
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0011884
Disease: Diabetic Retinopathy
Diabetic Retinopathy 		0.210 Biomarker RGD Upregulation of miR-195 accelerates oxidative stress-induced retinal endothelial cell injury by targeting mitofusin 2 in diabetic rats. 28487236

2017
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0151744
Disease: Myocardial Ischemia
Myocardial Ischemia 		0.210 Therapeutic RGD Vagal nerve stimulation improves mitochondrial dynamics via an M3 receptor/CaMKKβ/AMPK pathway in isoproterenol-induced myocardial ischaemia. 27491814

2017
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0034069
Disease: Pulmonary Fibrosis
Pulmonary Fibrosis 		0.210 Therapeutic RGD [The interventional effect of Xuebijing injection on expression of mitochondrial fusion protein 2 and the ultrastructure changes in lung tissues in rats with paraquat poisoning]. 24912636

2014
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Biomarker RGD Exogenous H 27998959

2017
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0011853
Disease: Diabetes Mellitus, Experimental
Diabetes Mellitus, Experimental 		0.200 Therapeutic RGD Early energy metabolism-related molecular events in skeletal muscle of diabetic rats: The effects of l-arginine and SOD mimic. 28483572

2017
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0677050
Disease: Manganese Poisoning
Manganese Poisoning 		0.200 Biomarker RGD Downregulation of Mfn2 participates in manganese-induced neuronal apoptosis in rat striatum and PC12 cells. 28232070

2017
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.200 Therapeutic RGD Melatonin enhances mitophagy and mitochondrial biogenesis in rats with carbon tetrachloride-induced liver fibrosis. 26882442

2016
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0362046
Disease: Prediabetes syndrome
Prediabetes syndrome 		0.200 Biomarker RGD Diastolic dysfunction in prediabetic male rats: Role of mitochondrial oxidative stress. 27521417

2016
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury 		0.200 Biomarker RGD Effect of ambient PM(2.5) on lung mitochondrial damage and fusion/fission gene expression in rats. 25560372

2015
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C1397307
Disease: Cardiac fibrosis
Cardiac fibrosis 		0.200 Biomarker RGD MicroRNA-214 Mediates Isoproterenol-induced Proliferation and Collagen Synthesis in Cardiac Fibroblasts. 26692091

2015
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C2750440
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Effects of salvianolic acid B on liver mitochondria of rats with nonalcoholic steatohepatitis. 26401075

2015
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C2750441
Disease: LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1
LIVER DISEASE, ALCOHOLIC, SUSCEPTIBILITY TO, 1 		0.200 Therapeutic RGD Effects of salvianolic acid B on liver mitochondria of rats with nonalcoholic steatohepatitis. 26401075

2015
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C3150651
Disease: FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2
FATTY LIVER DISEASE, NONALCOHOLIC, SUSCEPTIBILITY TO, 2 		0.200 Therapeutic RGD Effects of salvianolic acid B on liver mitochondria of rats with nonalcoholic steatohepatitis. 26401075

2015
Entrez Id: 9927
Gene Symbol: MFN2
MFN2
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack 		0.200 Biomarker RGD Mfn2 downregulation in excitotoxicity causes mitochondrial dysfunction and delayed neuronal death. 25147362

2014