Source: ANIMAL_MODELS

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Integrin-modulating therapy prevents fibrosis and autoimmunity in mouse models of scleroderma. 24107997

2013
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes. 11168809

2001
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD The Tight skin mouse: demonstration of mutant fibrillin-1 production and assembly into abnormal microfibrils. 9490728

1998
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Increased alpha 1(I) procollagen gene expression in tight skin (TSK) mice myocardial fibroblasts is due to a reduced interaction of a negative regulatory sequence with AP-1 transcription factor. 7721853

1995
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Transforming growth factor-beta 1 and collagen gene expression during postnatal skin development and fibrosis in the tight-skin mouse. 7783425

1995
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Cardiac collagen changes during the development of right ventricular hypertrophy in tight-skin mice with emphysema. 8070538

1994
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Tight-skin mouse an experimental model for scleroderma. 7523551

1994
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Tight-skin mouse autoantibody repertoire: analysis of VH and VK gene usage. 7688852

1993
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Increased collagen synthesis and increased content of type VI collagen in myocardium of tight skin mice. 8221765

1993
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Granulated metrial gland cells in the pregnant uterus of mice expressing the collagen mutation tight-skin (Tsk/+). 1617705

1992
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Urinary bladder function in the tight-skin mouse. 1433576

1992
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Lung collagen synthesis and deposition in tight-skin mice with genetic emphysema. 1587342

1992
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Decreased collagen mRNA and regression of cardiac fibrosis in the ventricular myocardium of the tight skin mouse following thyroid hormone treatment. 1451140

1992
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Electron microscopic observations of elastic fibres in the lung and aorta of tight-skin and beta-aminopropionitrile-fed mice. 1576433

1992
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Increased collagen biosynthesis and increased expression of type I and type III procollagen genes in tight skin (TSK) mouse fibroblasts. 2416757

1986
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Mast cells and their degranulation in the Tsk mouse model of scleroderma. 4048170

1985
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Hereditary emphysema in the tight-skin mouse. Evaluation of pathogenesis. 6562869

1984
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Delayed-type hypersensitivity to elastase-soluble lung peptides in the tight-skin (Tsk) mouse. 6604585

1983
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Glycosaminoglycan content in skin of the tight-skin mouse. 6847727

1983
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD Hereditary emphysema in the tight-skin (Tsk/+) mouse. 7271067

1981
Entrez Id: 2200
Gene Symbol: FBN1
FBN1
CUI: C0036421
Disease: Systemic Scleroderma
Systemic Scleroderma 		0.300 Biomarker MGD The tight-skin mouse: an animal model of inherited emphysema. 6971670

1980