Source: CLINGEN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker CLINGEN Mutational inactivation of the gene WRN causes Werner syndrome, an autosomal recessive disease characterized by premature aging, elevated genomic instability and increased cancer incidence. 15235603

2004
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker CLINGEN The gene defective in WS, WRN, encodes a DNA helicase. 10757812

2000
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker CLINGEN Primary tail fibroblast cultures from K577M-WRN mice showed three characteristics of WS cells: hypersensitivity to 4-nitroquinoline-1-oxide (4NQO), reduced replicative potential, and reduced expression of the endogenous WRN protein. 10628995

2000
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker CLINGEN Rothmund-Thomson syndrome due to RECQ4 helicase mutations: report and clinical and molecular comparisons with Bloom syndrome and Werner syndrome. 10678659

2000
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker CLINGEN Analysis of helicase gene mutations in Japanese Werner's syndrome patients. 9048918

1997
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker CLINGEN The gene responsible for WS (known as WRN) was identified by positional cloning. 8602509

1996
Entrez Id: 7486
Gene Symbol: WRN
WRN
CUI: C0043119
Disease: Werner Syndrome
Werner Syndrome 		1.000 Biomarker CLINGEN Accelerated loss of telomeric repeats may not explain accelerated replicative decline of Werner syndrome cells. 8641691

1996