Source: CLINGEN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN Cancer Susceptibility Gene Mutations in Individuals With Colorectal Cancer. 28135145

2017
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN Homozygous inactivation of CHEK2 is linked to a familial case of multiple primary lung cancer with accompanying cancers in other organs. 27900359

2016
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN Increased microtubule assembly rates influence chromosomal instability in colorectal cancer cells. 24976383

2014
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN Meta-analysis of CHEK2 1100delC variant and colorectal cancer susceptibility. 21807500

2011
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN CHEK2 mutations and HNPCC-related colorectal cancer. 19876921

2010
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN The CHEK2 gene I157T mutation and other alterations in its proximity increase the risk of sporadic colorectal cancer in the Czech population. 18996005

2009
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN CHEK2 1100delC is a susceptibility allele for HNPCC-related colorectal cancer. 18676774

2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN Alterations of Chk1 and Chk2 expression in colon cancer. 18679694

2008
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN DNA damage during reoxygenation elicits a Chk2-dependent checkpoint response. 16478982

2006
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis. 15829956

2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN Homozygosity for a CHEK2*1100delC mutation identified in familial colorectal cancer does not lead to a severe clinical phenotype. 15818573

2005
Entrez Id: 11200
Gene Symbol: CHEK2
CHEK2
CUI: C1333991
Disease: Hereditary Non-Polyposis Colon Cancer Type 2
Hereditary Non-Polyposis Colon Cancer Type 2 		0.300 Biomarker CLINGEN The CHEK2 1100delC mutation identifies families with a hereditary breast and colorectal cancer phenotype. 12690581

2003