×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
FNDC3B is another novel partner fused to RARA in the t(3;17)(q26;q21) variant of acute promyelocytic leukemia .
28314734 2017
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
We identified one ATO-resistant t-APL patient, who presented a PML A216T mutation in both the rearranged and unrearranged PML alleles, and two mutations in the rearranged RARA gene.
26728337 2016
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
This is the first report showing involvement of IRF2BP2 in APL , and it expands the list of novel RARA partners identified in APL .
25583766 2015
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
Mutations of Epigenetic Modifier Genes as a Poor Prognostic Factor in Acute Promyelocytic Leukemia Under Treatment With All-Trans Retinoic Acid and Arsenic Trioxide.
26285909 2015
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
Understanding the molecular mechanisms regulating PLZF/RARA protein stability would provide novel therapeutic targets for PLZF/RARA -associated APL .
23208507 2013
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
In most cases of acute promyelocytic leukemia , the PML and retinoic acid receptor alpha (RARA ) genes are translocated, resulting in expression of oncogenic PML-RARα fusion proteins.
22213200 2012
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
Missense mutations in PML-RARA are critical for the lack of responsiveness to arsenic trioxide treatment.
21613260 2011
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
Evidence for direct involvement of epirubicin in the formation of chromosomal translocations in t(15;17) therapy-related acute promyelocytic leukemia.
19884644 2010
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
All Trans Retinoic Acid (ATRA) induced myositis.
19887701 2009
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
[Can As2O3 improve the prognosis of childhood acute promyelocytic leukemia?--A single center experience].
19035177 2008
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
Thus, whereas transcriptional activation of PML-RARA is likely to control differentiation, its catabolism triggers LIC eradication and long-term remission of mouse APL .
19029980 2008
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
[Application of all-trans retinoic acid combining chemotherapy and As4S4 in the maintenance treatment of patients with acute promyelocytic leukemia].
17649720 2007
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
This novel PRKAR1A-RARA gene rearrangement is the fifth variant APL in which the RARA partner gene has been identified and the second known rearrangement of PRKAR1A in a malignant disease.
17712046 2007
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
Promyelocytic leukemia activates Chk2 by mediating Chk2 autophosphorylation.
16835227 2006
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
In one such disease, acute promyelocytic leukemia (APL ), a promyelocytic leukemia -retinoic acid receptor alpha (PML-RARalpha ) fusion protein is expressed as a result of a t(15;17) chromosomal translocation.
16788101 2006
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
[Therapeutic results with apl 93 protocol in acute promyelocytic leukemia (34 cases)].
17294898 2006
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
ATR, PML, and CHK2 play a role in arsenic trioxide-induced apoptosis.
16891316 2006
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
Acute promyelocytic leukemia (APL ) cells express promyelocytic leukemia /retinoic acid receptor alpha (PML/RARalpha) fusion protein, which leads to the blocking of APL cell differentiation.16935935 2006
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
Aberrant promoter methylation of the retinoic acid receptor alpha gene in acute promyelocytic leukemia .
16239915 2005
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
[Improved RT-PCR for detection of PML/RARalpha fusion gene in rapid diagnosis of acute promyelocytic leukemia].
14706140 2003
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
Expression of NPM-RARalpha fusion gene in hematopoietic cells confers sensitivity to troglitazone-induced apoptosis.
14508522 2003
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
Pseudotumor cerebri induced by all-trans-retinoic acid in a child treated for acute promyelocytic leukemia.
10742073 2000
×
Entrez Id: 5914
Gene Symbol: RARA
RARA
Acute Promyelocytic Leukemia
0.700
Biomarker
CTD_human
All-trans-retinoic acid (ATRA) responsive skin relapses of acute promyelocytic leukaemia followed by ATRA-induced pseudotumour cerebri.
8616088 1996