Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human Genetic Determinants of Methotrexate Toxicity in Tunisian Patients with Rheumatoid Arthritis: A Study of Polymorphisms Involved in the MTX Metabolic Pathway. 26077125

2016

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human Genetic polymorphisms in candidate genes predict increased toxicity with methotrexate therapy in Lebanese children with acute lymphoblastic leukemia. 25007187

2014

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human Methotrexate-induced subacute neurotoxicity in a child with acute lymphoblastic leukemia carrying genetic polymorphisms related to folate homeostasis. 21064136

2011

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human Methotrexate-induced myelopathy responsive to substitution of multiple folate metabolites. 19821069

2010

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human Methotrexate in pediatric osteosarcoma: response and toxicity in relation to genetic polymorphisms and dihydrofolate reductase and reduced folate carrier 1 expression. 19159907

2009

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human Methylenetetrahydrofolate reductase C677T and A1298C gene polymorphisms and therapy-related toxicity in children treated for acute lymphoblastic leukemia and non-Hodgkin lymphoma. 19391036

2009

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human Renal failure after high-dose methotrexate in a child homozygous for MTHFR C677T polymorphism. 17387702

2008

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice. 18551038

2008

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice. 17502830

2007

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human Severe encephalopathy induced by the first but not the second course of high-dose methotrexate mirrored by plasma homocysteine elevations and preceded by extreme differences in pretreatment plasma folate. 16166815

2005

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041755
Disease: Adverse reaction to drug
Adverse reaction to drug
0.300 Biomarker CTD_human MTX-induced white matter changes are associated with polymorphisms of methionine metabolism. 15753437

2005