Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human Risk factors for the onset and progression of Huntington disease. 28111121

2017
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human Functional changes in postsynaptic adenosine A(2A) receptors during early stages of a rat model of Huntington disease. 21867705

2011
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human Loss of striatal type 1 cannabinoid receptors is a key pathogenic factor in Huntington's disease. 20929960

2011
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human Combination therapy with coenzyme Q10 and creatine produces additive neuroprotective effects in models of Parkinson's and Huntington's diseases. 19476553

2009
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human DNA breakage and induction of DNA damage response proteins precede the appearance of visible mutant huntingtin aggregates. 18831068

2009
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human Allele-specific silencing of mutant Huntington's disease gene. 19094060

2009
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human A small-molecule therapeutic lead for Huntington's disease: preclinical pharmacology and efficacy of C2-8 in the R6/2 transgenic mouse. 17925440

2007
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human Transcriptional repression of PGC-1alpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration. 17018277

2006
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human Early behavioral deficits in R6/2 mice suitable for use in preclinical drug testing. 16137562

2005
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human Molecular mediators, environmental modulators and experience-dependent synaptic dysfunction in Huntington's disease. 15218539

2004
Entrez Id: 3064
Gene Symbol: HTT
HTT
CUI: C0393574
Disease: Huntington Disease, Late Onset
Huntington Disease, Late Onset 		0.300 Biomarker CTD_human Expanded huntingtin activates the c-Jun terminal kinase/c-Jun pathway prior to aggregate formation in striatal neurons in culture. 15312898

2004