Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Virgin coconut oil (VCO) by normalizing NLRP3 inflammasome showed potential neuroprotective effects in Amyloid-β induced toxicity and high-fat diet fed rat. 29729307

2018
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease. 28448946

2017
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human [Gly14]-Humanin Protects Against Amyloid β Peptide-Induced Impairment of Spatial Learning and Memory in Rats. 27306655

2016
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Lactational exposure of mice to low levels of non-dioxin-like polychlorinated biphenyls increases susceptibility to neuronal stress at a mature age. 26480858

2016
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Ethosuximide Induces Hippocampal Neurogenesis and Reverses Cognitive Deficits in an Amyloid-β Toxin-induced Alzheimer Rat Model via the Phosphatidylinositol 3-Kinase (PI3K)/Akt/Wnt/β-Catenin Pathway. 26420483

2015
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Selective activation of α7 nicotinic acetylcholine receptor by PHA-543613 improves Aβ25-35-mediated cognitive deficits in mice. 25881725

2015
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Potassium 2-(1-hydroxypentyl)-benzoate promotes long-term potentiation in Aβ1-42-injected rats and APP/PS1 transgenic mice. 24858312

2014
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Notoginsenoside R1 increases neuronal excitability and ameliorates synaptic and memory dysfunction following amyloid elevation. 25213453

2014
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms. 23827522

2013
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Protective effects of astragalosides on dexamethasone and Aβ25-35 induced learning and memory impairments due to decrease amyloid precursor protein expression in 12-month male rats. 22484447

2012
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Intraneuronal beta-amyloid accumulation in the amygdala enhances fear and anxiety in Alzheimer's disease transgenic mice. 19664757

2010
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Atorvastatin prevents hippocampal cell death, neuroinflammation and oxidative stress following amyloid-β(1-40) administration in mice: evidence for dissociation between cognitive deficits and neuronal damage. 20816828

2010
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Evaluation of the protective role of melatonin on the behavioral effects of aluminum in a mouse model of Alzheimer's disease. 19770021

2009
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Release of acetylcholinesterase (AChE) from beta-amyloid plaques assemblies improves the spatial memory impairments in APP-transgenic mice. 18599028

2008
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Adenosine A2A receptor blockade prevents memory dysfunction caused by beta-amyloid peptides but not by scopolamine or MK-801. 18191838

2008
Entrez Id: 351
Gene Symbol: APP
APP
CUI: C0751293
Disease: Memory Disorder, Semantic
Memory Disorder, Semantic 		0.300 Biomarker CTD_human Beta-amyloid (1-42)-induced learning and memory deficits in mice: involvement of oxidative burdens in the hippocampus and cerebral cortex. 15364477

2004