Source: CTD_human

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Dynamics of clonal evolution in myelodysplastic syndromes. 27992414

2017
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Palbociclib treatment of FLT3-ITD+ AML cells uncovers a kinase-dependent transcriptional regulation of FLT3 and PIM1 by CDK6. 27099147

2016
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Preclinical evaluation of AMG 925, a FLT3/CDK4 dual kinase inhibitor for treating acute myeloid leukemia. 24526162

2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human BET protein antagonist JQ1 is synergistically lethal with FLT3 tyrosine kinase inhibitor (TKI) and overcomes resistance to FLT3-TKI in AML cells expressing FLT-ITD. 25053825

2014
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Overexpression of Bcl2 protein predicts chemoresistance in acute myeloid leukemia: its correlation with FLT3. 23906301

2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Mechanisms of apoptosis induction by simultaneous inhibition of PI3K and FLT3-ITD in AML cells in the hypoxic bone marrow microenvironment. 23036488

2013
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Ponatinib may overcome resistance of FLT3-ITD harbouring additional point mutations, notably the previously refractory F691I mutation. 22409268

2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Combined effects of FLT3 and NF-κB selective inhibitors on acute myeloid leukemia in vivo. 21928377

2012
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Potent activity of ponatinib (AP24534) in models of FLT3-driven acute myeloid leukemia and other hematologic malignancies. 21482694

2011
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice. 21441929

2011
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Micro-RNAs and copy number changes: new levels of gene regulation in acute myeloid leukemia. 19822134

2010
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Dual treatment with FLT3 inhibitor SU11657 and doxorubicin increases survival of leukemic mice. 17184839

2007
Entrez Id: 2322
Gene Symbol: FLT3
FLT3
CUI: C1879321
Disease: Acute Myeloid Leukemia (AML-M2)
Acute Myeloid Leukemia (AML-M2) 		0.520 Biomarker CTD_human Synergistic effect of arsenic trioxide and flt3 inhibition on cells with flt3 internal tandem duplication. 17050201

2006