Source: CTD_mouse

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0029463
Disease: Osteosarcoma
Osteosarcoma
1.000 Biomarker CTD_mouse Ezrin Inhibition Up-regulates Stress Response Gene Expression. 27137931

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1261473
Disease: Sarcoma
Sarcoma
1.000 Biomarker CTD_mouse In Trp53 haploinsufficient mice, the HBV transgene increased the risk of sarcoma in males and females (p < .001). 19258306

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1261473
Disease: Sarcoma
Sarcoma
1.000 Biomarker CTD_mouse There was no loss of heterozygosity at the wildtype Trp53 locus in twenty-five sarcomas or four hepatocellular tumors examined. 19258306

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1261473
Disease: Sarcoma
Sarcoma
1.000 Biomarker CTD_mouse Trp53 haploinsufficiency was associated with increased sarcoma incidence in males and females (p < .001). 19258306

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C1261473
Disease: Sarcoma
Sarcoma
1.000 Biomarker CTD_mouse No mutations were identified in the mRNA (exons 2-11) of Trp53 in six liver neoplasms or twenty-four sarcomas. 19258306

2009

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.900 Biomarker CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.900 Biomarker CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0017638
Disease: Glioma
Glioma
0.900 Biomarker CTD_mouse PRC2 loss amplifies Ras-driven transcription and confers sensitivity to BRD4-based therapies. 25119042

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0030297
Disease: Pancreatic Neoplasm
Pancreatic Neoplasm
0.900 Biomarker CTD_mouse Functions of TAp63 and p53 in restraining the development of metastatic cancer. 23873029

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas
0.900 Biomarker CTD_mouse To investigate whether simultaneous depletion of both p53 and TAp63 can recapitulate the effect of mutant p53 expression in vivo, we used a mouse model of pancreatic cancer in which the expression of mutant p53 resulted in the rapid appearance of primary tumours and metastases. 23873029

2014

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker CTD_mouse p53 Mutations are very common in human hepatocellular carcinoma, and induction of hepatic p53 expression causes lysis of implanted hepatoblastoma cells in a chimeric mouse. 19919837

2010

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker CTD_mouse Here, in a hepatocellular carcinoma-prone model brought about through toxin-induced hepatocyte injury and regeneration, we sought to determine the cooperative interactions of germ line p53 mutation and telomere dysfunction [produced by telomerase reverse transcriptase (mTERT) gene knockout]. 16651430

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker CTD_mouse In the setting of intact telomeres, p53 mutation had no effect on hepatocarcinogenesis, whereas in the setting of telomere dysfunction, p53 mutation enabled advanced hepatocellular carcinoma disease. 16651430

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker CTD_mouse Thus, this study supports a model that, in the face of chronic liver damage, attenuated p53 function and telomere-induced chromosomal instability play critical and cooperative roles in the progression of hepatocellular carcinoma. 16651430

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker CTD_mouse Hepatocellular carcinoma is commonly associated with physical or functional inactivation of the p53 tumor suppressor, high levels of chromosomal instability, and disease conditions causing chronic cycles of hepatocyte death and regeneration. 16651430

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker CTD_mouse Notably, there was no evidence of deletion or mutation of the wild-type p53 allele in the late generation mTert(-/-)p53(+/-) mice, suggesting that reduced levels of p53 potently enable hepatocellular carcinoma progression in the setting of telomere dysfunction. 16651430

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C2239176
Disease: Liver carcinoma
Liver carcinoma
0.900 Biomarker CTD_mouse Cooperative interactions of p53 mutation, telomere dysfunction, and chronic liver damage in hepatocellular carcinoma progression. 16651430

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0006142
Disease: Malignant neoplasm of breast
Malignant neoplasm of breast
0.900 Biomarker CTD_mouse Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice. 12165863

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0678222
Disease: Breast Carcinoma
Breast Carcinoma
0.900 Biomarker CTD_mouse Frequent mutations of the Trp53, Hras1 and beta-catenin (Catnb) genes in 1,3-butadiene-induced mammary adenocarcinomas in B6C3F1 mice. 12165863

2002

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.800 Biomarker CTD_mouse Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. 26390243

2016

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms
0.800 Biomarker CTD_mouse These results provide the in vivo experimental evidence of synergistic interactions of ras and p53 in lung tumor progression. 16247444

2006

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung
0.800 Biomarker CTD_mouse A mouse model for tumor progression of lung cancer in ras and p53 transgenic mice. 16247444

2006

Entrez Id: 5071
Gene Symbol: PRKN
PRKN
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease
0.800 Biomarker CTD_mouse In the present study, we examined the status of cannabinoid CB(1) receptors in the basal ganglia of female and male Park-2 knockout mice, a genetic model of PD that progresses with no neuronal death and that may be considered representative of early and presymptomatic parkinsonian deficits. 15882845

2005

Entrez Id: 7157
Gene Symbol: TP53
TP53
CUI: C0007114
Disease: Malignant neoplasm of skin
Malignant neoplasm of skin
0.700 Biomarker CTD_mouse Whole-Exome Sequencing Validates a Preclinical Mouse Model for the Prevention and Treatment of Cutaneous Squamous Cell Carcinoma. 27923803

2017