Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression LHGDN Expression of the WT1 gene -KTS domain isoforms suppresses the invasive ability of human lung squamous cell carcinoma cells. 18202757

2008
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 GeneticVariation LHGDN However, P21 protein expression in OSCC tumours is affected by P21 / WAF1 genotype. 18251939

2008
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression LHGDN [Alterations of cell cycle regulating proteins: Rb, p21 and p16 in laryngeal cancer]. 18546941

2007
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 Biomarker LHGDN Cell cycle regulating proteins p21 and p27 in prognosis of oral squamous cell carcinomas. 17203174

2007
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 Biomarker LHGDN Opposite effect of ERK1/2 and JNK on p53-independent p21WAF1/CIP1 activation involved in the arsenic trioxide-induced human epidermoid carcinoma A431 cellular cytotoxicity. 16283431

2006
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 GeneticVariation LHGDN Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck. 15878916

2005
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression LHGDN p21WAF1/CIP1 expression is a marker of poor prognosis in oral squamous cell carcinoma. 15817070

2005
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression LHGDN Deregulated p21(WAF1) overexpression impacts survival of surgically resected esophageal squamous cell carcinoma patients. 16122475

2005
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 Biomarker LHGDN These results show that the differentiation-inducing agents, particularly SB, suppress growth of oral squamous carcinoma cells through apoptosis and induce cell differentiation possibly through mechanisms involving COX-2, p27Kip1 and/or p21WAF1/Cip1 in vitro and in vivo. 15645120

2005
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 Biomarker LHGDN Loss of p21WAF1/CIP1 expression in invasive fronts of oral tongue squamous cell carcinomas is correlated with tumor progression and poor prognosis. 16142340

2005
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 Biomarker LHGDN Comparison between immunohistochemical expression of cyclin D1 and p21 and histological malignancy graduation of oral squamous cell carcinomas. 15776189

2004
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression LHGDN Protein levels of p21, p27, cyclin E and Bax predict sensitivity to cisplatin and paclitaxel in head and neck squamous cell carcinomas. 14719078

2004
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression LHGDN Differential expressions of cyclin-dependent kinase inhibitors (p27 and p21) and their relation to p53 and Ki-67 in oral squamous tumorigenesis. 12527941

2003
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression LHGDN Critical role of both p27KIP1 and p21CIP1/WAF1 in the antiproliferative effect of ZD1839 ('Iressa'), an epidermal growth factor receptor tyrosine kinase inhibitor, in head and neck squamous carcinoma cells. 12599217

2003
Entrez Id: 1026
Gene Symbol: CDKN1A
CDKN1A
CUI: C0007137
Disease: Squamous cell carcinoma
Squamous cell carcinoma 		0.100 AlteredExpression LHGDN The clinicopathological significance of p53 and p21 expression in squamous cell carcinoma of hypopharyngeal cancer. 14607337

2003