Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0017638
Disease: Glioma
Glioma 		0.100 AlteredExpression LHGDN Here we investigated the role of HIF-1alpha and HIF-2alpha in the regulation of SK1 during hypoxic stress in glioma-derived U87MG cells. 18055454

2008
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0017638
Disease: Glioma
Glioma 		0.100 Biomarker LHGDN We found that RNAi can be used to significantly attenuate glioma growth by reducing HIF-1alpha levels constitutively using short hairpin RNAs and transiently using small interfering RNAs (siRNA). 17438103

2007
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0017638
Disease: Glioma
Glioma 		0.100 AlteredExpression LHGDN We demonstrate that noscapine treatment of human glioma U87MG and T98G cell lines exposed to the hypoxic mimetic agent, CoCl2, inhibits hypoxia-mediated HIF-1alpha expression and transcriptional activity as measured by decreased secretion of VEGF, a HIF-1 target gene. 16596228

2006
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0017638
Disease: Glioma
Glioma 		0.100 AlteredExpression LHGDN VEGF and HIF-1 expression was high in glioma cell lines even under normoxia, and increased after exposure to hypoxia or growth factor stimulation. 16612574

2006
Entrez Id: 3091
Gene Symbol: HIF1A
HIF1A
CUI: C0017638
Disease: Glioma
Glioma 		0.100 AlteredExpression LHGDN Exposure to hypoxia induced significant expression of CXCR4 and HIF-1alpha in glioma cells, whereas treatment with exogenous VEGF increased CXCR4 expression in HBMECs. 17075581

2006