Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0017638
Disease: Glioma
Glioma 		0.040 GeneticVariation LHGDN Furthermore, the multifactor dimensionality reduction and classification and regression tree analyses identified MGMT F84L as the predominant risk factor for glioma and revealed strong interactions among ionizing radiation exposure, PARP1 A762V, MGMT F84L, and APEX1 E148D. 19124499

2009
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0017638
Disease: Glioma
Glioma 		0.040 AlteredExpression LHGDN We show that antisense oligonucleotides directed against Ape1/Ref-1 in SNB19, a human glioma cell line lacking O(6)-methylguanine-DNA-methyltransferase, mediate both reduction in Ape1/Ref-1 protein and Ap endo activity and concurrent reduction in resistance to methyl methanesulfonate and the clinical alkylators temozolomide and 1,3-(2-chloroethyl)-1-nitrosourea. 12231548

2002
Entrez Id: 328
Gene Symbol: APEX1
APEX1
CUI: C0017638
Disease: Glioma
Glioma 		0.040 AlteredExpression LHGDN Apurinic/apyrimidinic endonuclease activity is elevated in human adult gliomas. 11705870

2001