DisGeNET - a database of gene-disease associations

Source: LHGDN

Disease: Leukemia, Myelocytic, Acute ×

Gene: CXCL12 ×

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	6387
Gene Symbol:	CXCL12

CXCL12

CUI:	C0023467
Disease:	Leukemia, Myelocytic, Acute

Leukemia, Myelocytic, Acute

0.100

GeneticVariation

LHGDN

No role for CXCL12-G801A polymorphism in the development of extramedullary disease in acute myeloid leukemia.

17805324

2008

Entrez Id:	6387
Gene Symbol:	CXCL12

CXCL12

CUI:	C0023467
Disease:	Leukemia, Myelocytic, Acute

Leukemia, Myelocytic, Acute

0.100

Biomarker

LHGDN

We hypothesized that a polymorphism in the SDF-1 coding gene (CXCL12 G801A) could influence blast dissemination and tissue infiltration in AML.

16818471

2006