Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression LHGDN These results suggest that Apaf-1 expression may become a prognostic marker for progress of human cutaneous melanoma and further support the notion that loss of Apaf-1 may be an important contributory factor in the development of the disease. 16420245

2006
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression LHGDN These data demonstrated that there is an inverse correlation between Apaf-1 expression and pathologic stage of melanoma. 15649154

2005
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression LHGDN Is Apaf-1 expression frequently abrogated in melanoma? 15832174

2005
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression LHGDN Expression and function of the apoptosis effector Apaf-1 in melanoma. 15832175

2005
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker LHGDN Role of Apaf-1, a key regulator of apoptosis, in melanoma progression and chemoresistance. 16232302

2005
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0025202
Disease: melanoma
melanoma 		0.100 GeneticVariation LHGDN In metastatic melanomas, APAF-1 loss significantly correlated with a worse prognosis (P < 0.05) in the patients, and its loss during melanoma tumor progression suggests that APAF-1 is a tumor suppressor gene. 15026369

2004
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression LHGDN We conclude that loss of APAF-1 expression can be considered as an indicator of malignant transformation in melanoma. 15009102

2004
Entrez Id: 317
Gene Symbol: APAF1
APAF1
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression LHGDN Our data showed that Apaf-1 expression is significantly reduced in melanoma cells compared with normal nevi (chi(2)=6.02, P=0.014). 15305193

2004