Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker LHGDN The serum VEGF (P = 0.034) and Bcl-2 (P = 0.005) levels were significantly higher in patients with melanoma than in the control group. 18363112

2008
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression LHGDN IGF1 promotes resistance to apoptosis in melanoma cells through an increased expression of BCL2, BCL-X(L), and survivin. 18079751

2008
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression LHGDN In contrast, Bcl-XL and Mcl-1 were expressed at lower levels in nevi and thin melanoma compared to Bcl-2 but their expression was much higher in thick melanoma and in subcutaneous and lymph node metastases (P<0.0001). 17384650

2007
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker LHGDN The baseline serum bcl-2 levels were significantly higher in patients with melanoma than in the control group (P=0.01). 15577328

2004
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0025202
Disease: melanoma
melanoma 		0.100 Biomarker LHGDN This linkage helps explain the vital roles of both Mitf and Bcl2 in the melanocyte lineage and the well-known treatment resistance of melanoma. 12086670

2002
Entrez Id: 596
Gene Symbol: BCL2
BCL2
CUI: C0025202
Disease: melanoma
melanoma 		0.100 AlteredExpression LHGDN Bcl-2 overexpression prevents apoptosis induced by ceramidase inhibitors in malignant melanoma and HaCaT keratinocytes. 11959101

2002