Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.400 AlteredExpression LHGDN In conclusion, we propose a novel signaling pathway of MMP-9 up-regulation in CC cells such that TNF-alpha induces the activation of COX-2 and PGE2 via TNF-R1 followed by the up-regulation of MMP-9 via the PGE2 (EP2/4) receptor. 19218340

2009
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.400 Biomarker LHGDN Cyclooxygenase-2-overexpressing human cholangiocarcinoma cell line QBC939 and cyclooxygenase-2-deficient human cholangiocarcinoma cell line SK-CHA-1 were used in the present study. 12800245

2003
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.400 AlteredExpression LHGDN The overexpression of COX-2 plays a crucial role in the carcinogenesis and development of extra-hepatic cholangiocarcinoma, indicating that COX-2 may serve as a target for chemoprevention of extra-hepatic cholangiocarcinoma. 14607721

2002
Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0206698
Disease: Cholangiocarcinoma
Cholangiocarcinoma 		0.400 AlteredExpression LHGDN The results also suggest ERBB-2 and COX-2 as potentially important targets relevant to chemoprevention or adjunct therapy of ChC. 12143054

2002