Source: LHGDN

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 Biomarker LHGDN We were able to demonstrate progranulin immunoreactivity throughout the medial temporal lobe in all dementia with Lewy body cases. 18955727

2009
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN In vivo and postmortem clinicoanatomical correlations in frontotemporal dementia and parkinsonism linked to chromosome 17. 18322394

2008
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN Molecular characterization of novel progranulin (GRN) mutations in frontotemporal dementia. 18183624

2008
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 Biomarker LHGDN Progranulin mutation causes frontotemporal dementia in the Swedish Karolinska family. 19012866

2008
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN Progranulin functions as a neurotrophic factor to regulate neurite outgrowth and enhance neuronal survival. 18378771

2008
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 Biomarker LHGDN Loss-of-function mutations in progranulin (GRN) cause ubiquitin- and TAR DNA-binding protein 43 (TDP-43)-positive frontotemporal dementia (FTLD-U), a progressive neurodegenerative disease affecting approximately 10% of early-onset dementia patients. 18723524

2008
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN It also demonstrates that half of the patients with a PGRN mutation in our series had no apparent family history of dementia. 17436289

2007
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology. 17439980

2007
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN Heterogeneity within a large kindred with frontotemporal dementia: a novel progranulin mutation. 17620546

2007
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN Mutations other than null mutations producing a pathogenic loss of progranulin in frontotemporal dementia. 17345602

2007
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN PGRN mutations at 17q21 may occur in apparently sporadic frontotemporal lobar dementia with ubiquitinated inclusions cases and in cases presenting with either primary progressive aphasia or the behavioral variant of frontotemporal dementia. 17522386

2007
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN Late-onset frontotemporal dementia associated with a novel PGRN mutation. 17417739

2007
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN The neuropathology and clinical phenotype of FTD with progranulin mutations. 17458552

2007
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 Biomarker LHGDN Null mutations in progranulin cause ubiquitin-positive frontotemporal dementia linked to chromosome 17q21. 16862115

2006
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN Mutations in progranulin are a major cause of ubiquitin-positive frontotemporal lobar degeneration. 16950801

2006
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0497327
Disease: Dementia
Dementia 		0.500 GeneticVariation LHGDN Characteristics of frontotemporal dementia patients with a Progranulin mutation. 16983677

2006