Source: MGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD Topical vitamin D3 and low-calcemic analogs induce thymic stromal lymphopoietin in mouse keratinocytes and trigger an atopic dermatitis. 16880407

2006
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD The observation that normalization of mineral ion homeostasis in the VDR-null mice prevents rachitic changes suggests that rickets is secondary to hypocalcemia, hypophosphatemia, or hyperparathyroidism, rather than impaired VDR action. 15976027

2005
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD Lack of the vitamin D receptor is associated with reduced epidermal differentiation and hair follicle growth. 11851870

2002
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD 1,25-Dihydroxyvitamin D(3) is a negative endocrine regulator of the renin-angiotensin system. 12122115

2002
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD RXR-alpha ablation in skin keratinocytes results in alopecia and epidermal alterations. 11171393

2001
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD Rickets and hyperparathyroidism caused by a defective vitamin D receptor (VDR) can be prevented in humans and animals by high calcium intake, suggesting that intestinal calcium absorption is critical for 1,25(OH)(2) vitamin D [1,25(OH)(2)D(3)] action on calcium homeostasis. 11687634

2001
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD Characterization of a vitamin D receptor knockout mouse as a model of colorectal hyperproliferation and DNA damage. 11532865

2001
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD In vitro and in vivo analysis of the immune system of vitamin D receptor knockout mice. 11697802

2001
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD Vitamin D receptor null mutant mice fed high levels of calcium are fertile. 11385068

2001
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. 10746634

2000
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD Genetic ablation of parathyroid glands reveals another source of parathyroid hormone. 10910362

2000
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD Mice lacking the vitamin D receptor exhibit impaired bone formation, uterine hypoplasia and growth retardation after weaning. 9241280

1997
Entrez Id: 7421
Gene Symbol: VDR
VDR
CUI: C0035579
Disease: Rickets
Rickets 		0.700 Biomarker MGD Studies in kindreds with VDR mutations (vitamin D-dependent rickets type II, VDDR II) have demonstrated hypocalcemia, hyperparathyroidism, rickets, and osteomalacia. 9275211

1997