DisGeNET - a database of gene-disease associations

Gene: GLE1 ×

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Gene

Disease

Variant

Source

Association Type

Semantic type

Protein Class

Disease Class

Type

Original DB

Consequence

DSI _g

DPI _g

pLI

EI _gda

EL _gda

Score _gda

PMID

PMID Year

AF_EXOME

Num. PMIDs

Num. SNPs_gda

AF_GENOME

Gene

Disease

Score _gda

Association Type

Original DB

Sentence supporting the association

PMID

PMID Year

Entrez Id:	2733
Gene Symbol:	GLE1

GLE1

CUI:	C0002736
Disease:	Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis

0.430

GermlineCausalMutation

ORPHANET

These results suggest a haploinsufficiency mechanism and point to a causative role for GLE1 mutations in ALS patients.

2015