Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker PSYGENET Thus, TMEM106B is an FTLD-TDP risk gene, with microRNA-132/212 depression as an event which can lead to aberrant overexpression of TMEM106B, which in turn alters progranulin pathways. 22895706

2012
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker PSYGENET The most common abnormal behaviours in SD were irritability, disinhibition, depression and abnormal appetite, in PNFA apathy, agitation and depression, in LPA anxiety, irritability, agitation and apathy, and in GRN-PPA apathy and irritability. 20400120

2010
Entrez Id: 2896
Gene Symbol: GRN
GRN
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.400 Biomarker PSYGENET In this study, we showed that progranulin-deficient mice displayed increased depression- and disinhibition-like behavior, as well as deficits in social recognition from a relatively young age. 20667979

2010