Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5142
Gene Symbol: PDE4B
PDE4B
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker PSYGENET Both phosphodiesterase-4B (PDE4B) and glycogen synthase kinase-3 (GSK-3) have common binding sites on N-terminal region of DISC1 and are implicated into etiology of schizophrenia and depression. 21376063

2012
Entrez Id: 5142
Gene Symbol: PDE4B
PDE4B
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker PSYGENET Enhanced long-term depression and impaired reversal learning in phosphodiesterase 4B-knockout (PDE4B-/-) mice. 21458469

2012
Entrez Id: 5142
Gene Symbol: PDE4B
PDE4B
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker PSYGENET Several studies indicated that PDE4B may be involved in the regulation of anxiety and depression. 21184794

2011
Entrez Id: 5142
Gene Symbol: PDE4B
PDE4B
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker PSYGENET The cyclic adenosine monophosphate-specific phosphodiesterase-4 (PDE4) gene family is the target of several potential therapeutic inhibitors and the PDE4B gene has been associated with schizophrenia and depression. 18090323

2007
Entrez Id: 5142
Gene Symbol: PDE4B
PDE4B
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.350 Biomarker PSYGENET Altered DISC1-PDE4B interaction may thus underlie the symptoms of some cases of schizophrenia and depression. 17823207

2007