Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6853
Gene Symbol: SYN1
SYN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET Q555X-hSynI induced larger facilitation and post-tetanic potentiation in excitatory synapses and stronger depression after long trains in inhibitory synapses. 23406870

2013

Entrez Id: 6853
Gene Symbol: SYN1
SYN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET Both the alteration of synapsin I and the depression-associated behavior were rapidly restored after treatment with mifepristone for 1 week. 17392736

2008

Entrez Id: 6853
Gene Symbol: SYN1
SYN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET Both SynI(-/-) and SynII(-/-) mice have a normal lifespan, but exhibit a decreased number of SVs and synaptic depression upon high-frequency stimulation. 18713831

2008

Entrez Id: 6853
Gene Symbol: SYN1
SYN1
CUI: C0011581
Disease: Depressive disorder
Depressive disorder
0.310 Biomarker PSYGENET Synapsin-II and double knockouts, but not synapsin-I knockouts, exhibit decreased post-tetanic potentiation and severe synaptic depression upon repetitive stimulation. 7777057

1995