Source: PSYGENET

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.320 Biomarker PSYGENET The association with TACR1 and BPAD, ADS, and ADHD suggests a shared molecular pathophysiology between these affective disorders. 24817687

2014
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.320 Biomarker PSYGENET Polymorphisms of sepiapterin reductase gene alter promoter activity and may influence risk of bipolar disorder. 19415819

2009
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.320 Biomarker PSYGENET It also discusses the promise of substance P-receptor antagonists (SPA) for the treatment of affective disorders and their proposed mechanism of action. 12692775

2003
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.320 Biomarker PSYGENET More recently, the neuropeptide substance P (SP) and its receptor (the neurokinin-1 receptor [NK1R]) have been implicated in the pathophysiology of affective disorders, including depression. 12562138

2002
Entrez Id: 6869
Gene Symbol: TACR1
TACR1
CUI: C0525045
Disease: Mood Disorders
Mood Disorders 		0.320 Biomarker PSYGENET These observations suggest that centrally-acting NK(1) receptor antagonists may have clinical utility in the treatment of a range of anxiety and mood disorders. 10818257

2000