Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Other interacting molecular signals, i.e., GSK-3?, convergent survival factors (brain-derived neurotrophic factor and heat shock proteins), and transition redox metals are also mentioned to emphasize the vast array of intermediates that could interact via comparable mechanisms in both MDD and AD. 24927694

2015

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Analyzing patient subgroups, GSK3B structural variants were found to be risk factors of BP particularly (P?=?0.00001) with an odds ratio of 8.1 while no such effect was shown in the MDD group. 24677591

2014

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Compared with healthy controls, MDD patients showed disruptions in the diurnal rhythms of the expression of PERIOD1, PERIOD2, CRY1, BMAL1, NPAS2, and GSK-3? and disruptions in the diurnal rhythms of the release of melatonin, VIP, cortisol, ACTH, IGF-1, and GH. 24001941

2014

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET Our findings show, for the first time, that GSK3? polymorphisms may play an important role in MDD endophenotypes, especially in anxiety symptoms. 23030648

2013

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C1269683
Disease: Major Depressive Disorder
Major Depressive Disorder
0.400 Biomarker PSYGENET This study presents further evidence of the contribution of GSK3? to mood disorders, implicating a specific SNP and a haplotype with an earlier onset of the disorder in a group of well-characterized patients with unipolar MDD. 20618448

2011