Source: RGD

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Therapeutic RGD For prevention, oral sCT reduced body weight by ∼16% to 19% (P < 0.001), reduced plasma insulin and leptin by ∼50%, and improved impaired fasting glycemia (P < 0.05) concomitantly with amelioration of IR (HOMA-IR; P < 0.01) in HFD- and OVX-induced obesity. 23793169

2014

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker RGD Generation of leptin-deficient Lepmkyo/Lepmkyo rats and identification of leptin-responsive genes in the liver. 23800849

2013

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker RGD Homozygous leptin null rats are obese with significantly higher serum cholesterol, triglyceride, and insulin levels than wild-type controls. 22948215

2012

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker RGD Rats fed with HFD had elevated levels of serum lipids, insulin, leptin, glucose and apolipoprotein B. Lipid peroxides and caspase-3 levels were increased while serum apolipoprotein A1 and antioxidant enzymes levels in heart tissues were decreased in HFD-induced obesity in rats as compared to normal healthy control rats fed on standard rat pellet diet. 21075806

2012

Entrez Id: 3952
Gene Symbol: LEP
LEP
CUI: C0028754
Disease: Obesity
Obesity
0.700 Biomarker RGD Central overexpression of leptin antagonist reduces wheel running and underscores importance of endogenous leptin receptor activity in energy homeostasis. 19726711

2009