×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
Encephalitis, St. Louis
0.100
Biomarker
BEFREE
The significantly higher frequency of homozygote individuals for the risk haplotype among Mexican SLE patients could be the result of genetic admixture, and suggests the possibility that IRF5 could be involved in the more active disease and organ involvement known to occur among Mexican SLE patients.
17476532
2007
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
Encephalitis, St. Louis
0.100
Biomarker
BEFREE
Opposed independent effects and epistasis in the complex association of IRF5 to SLE .
17568788
2007
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
Encephalitis, St. Louis
0.100
Biomarker
BEFREE
Association of IRF5 in UK SLE families identifies a variant involved in polyadenylation.
17189288
2007
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
Encephalitis, St. Louis
0.100
AlteredExpression
BEFREE
Contribution of IRF5 in B cells to the development of murine SLE -like disease through its transcriptional control of the IgG2a locus.
20479222
2010
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
Encephalitis, St. Louis
0.100
GeneticVariation
BEFREE
SLE -associated IRF5 haplotypes were correlated with the expression data and with the best cis-regulatory models.
21627826
2011
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
Encephalitis, St. Louis
0.100
Biomarker
BEFREE
SLE serum was identified as a trigger for IRF-5 nuclear accumulation; however, neither IFNα nor SLE immune complexes could induce nuclear localization.
21968701
2012
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
Encephalitis, St. Louis
0.100
AlteredExpression
BEFREE
RNA-Seq for enrichment and analysis of IRF5 transcript expression in SLE .
23349905
2013
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
Encephalitis, St. Louis
0.100
Biomarker
BEFREE
IRF5 is elevated in childhood-onset SLE and regulated by histone acetyltransferase and histone deacetylase inhibitors.
28525378
2017
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
Encephalitis, St. Louis
0.100
Biomarker
BEFREE
Coordination between innate immune cells, type I IFNs and IRF5 drives SLE pathogenesis.
31130331
2019
×
Entrez Id:
3663
Gene Symbol:
IRF5
IRF5
Encephalitis, St. Louis
0.100
Biomarker
BEFREE
Genetic Versus Non-genetic Drivers of SLE : Implications of IRF5 Dysregulation in Both Roads Leading to SLE .
30645688
2019