|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
These findings suggest that positive/high Oct-4 is more strongly linked to stage III/IV cancer and cancer grade of differentiation, and is correlated with malignant characteristics that lead to poor prognosis in different types of cancer, especially in Asian.
|
26575328 |
2016 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
GeneticVariation |
BEFREE |
Also, mRNA expression of transcriptional marker Nanog and Octamer-binding transcription factor 4 (OCT4), known to enhance malignancy and metastasis in lung adenocarcinoma, was suppressed in ZNF746 siRNA-transfected H460 NSCLC cells.
|
24145959 |
2014 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Further, various studies identified genes in cancer stem cells, which were previously shown to regulate the pluripotency circuitry, particularly the so-called "Yamanaka-Factors" (OCT4, KLF4, SOX2, and c-MYC).
|
26896855 |
2016 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Hypoxia also enhanced the expression of cancer stem cell (CSC) transcription factors (NANOG, Oct4, SOX2), CD133 and EMT markers (N-cadherin, Vimentin), thereby supporting invasion.
|
31634481 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
D7-6 G cells had increased expression of cancer stem cells markers Oct4, Sox2, and Nanog; aldehyde dehydrogenase expression and activity; proportion of CD44<sup>+</sup>CD24<sup>-</sup>cells.
|
30579251 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
The results demonstrated Wnt/β-catenin signaling was activated and was able to form mammospheres with increased cancer stem cell markers (ALDH1, NANOG, and OCT4) in endocrine-resistant cells.
|
31693936 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
In HCC-derived cells, SRY knockdown decreased OCT4 expression and cancer stem-like phenotypes such as self-renewal, chemoresistance, and tumorigenicity.
|
26013162 |
2015 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
More importantly, the expression levels of epithelial-mesenchymal transition biomarkers (N-cadherin and vimentin) and cell stemness biomarkers (nanog, sox2, and oct3/4) considerably increased in HepG2 with dopamine-induced SULT1A3/4, whereas in L02, epithelial-mesenchymal transition and cancer stem cell-associated proteins were contrarily decreased.
|
29025375 |
2017 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Furthermore, during ethanol-induced cellular transformation, cells gained the phenotypes of cancer stem cells (CSCs) by expressing pluripotency maintaining factors (Oct4, Sox2, cMyc and KLF4) and stem cell markers (CD24, CD44 and CD133).
|
29761897 |
2018 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Stemness state in cancer stem cells (CSCs) was evaluated by the changes of CSC biomarkers including Oct-4 and ABCG2.
|
26289851 |
2016 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Finally, we analyzed the expression and clinical significance of epithelial-to-mesenchymal transition (EMT) markers (E-cadherin and N-cadherin) and cancer stem cell (CSC) markers (Nanog, Oct-4, and Sox-2) in CRC tissues.
|
29081665 |
2017 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
The cell viability of mammospheres were evaluated by MTT assay and the OCT4 expression, a cancer stem cells marker, was verified by immunocitochemistry.
|
27671309 |
2017 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
POU5F1 (OCT4) is implicated in cancer stem cell self-renewal.
|
31012189 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
In addition, the expression of cancer stem cell (CSC) markers of Sox2 and Oct4 were higher than that in 2D cultured cells.
|
24142425 |
2014 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
The generation of induced pluripotent stem cells (iPSCs) from somatic cells by expressing ectopic reprogramming transcriptional factors such as Oct3/4, Sox2, Klf4, c-Myc, and Nanog is one of the cutting-edge discoveries in stem cell and cancer research.
|
24568610 |
2014 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Moreover, the nuclear localization of OCT3/4 protein in primordial follicle-enclosed oocytes suggests a possible increased activity of ovarian stem cells in response to chemotherapy and/or extragonadal cancer.
|
30857552 |
2019 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
In agreement, we find that FUT9 silencing decreases the expression of the colorectal cancer TIC marker CD44 and the level of the OCT4 transcription factor, which is known to support cancer stemness.
|
29196508 |
2017 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Differential expression of Oct4 variants and pseudogenes in normal urothelium and urothelial cancer.
|
23933063 |
2013 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Cancer stem cell-like cells (CSCLC) are reported to be a minor population in tumors or even in tumor cell lines which also express Oct4.
|
18701476 |
2008 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Both Oct3/4 and Sox2 were variably expressed in the cancer cell lines, but were either negative or very weakly expressed in the normal cell line.
|
19414369 |
2009 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
In conclusion, we demonstrated that Oct-4 expression plays a crucial role in maintaining the self-renewing, cancer stem-like, and chemoradioresistant properties of LC-CD133(+).
|
18612434 |
2008 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Resistant cell line consisted of a 70% side population fraction enriched with Oct4-positive cancer stem cells.
|
20596658 |
2010 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
We further demonstrated that inactivation of p38 is a potential mechanism contributing to acquisition and maintenance of cancer stem cell properties in non-small cell lung cancer (NSCLC) cells. p38, in particular the p38γ and p38δ isoforms, suppresses the cancer stem cell properties and tumor initiating ability of NSCLC cells by promoting the ubiquitylation and degradation of stemness proteins such as SOX2, Oct4, Nanog, Klf4 and c-Myc, through MK2-mediated phosphorylation of Hsp27 that is an essential component of the proteasomal degradation machinery.
|
28460458 |
2017 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Treatment of tumor-bearing mice with genotoxic chemotherapy not only prolonged survival and reduced tumor size but also selectively eliminated the OCT4-positive cancer stem cells.
|
29141221 |
2017 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Humanized Stem Cell Models of Pediatric Medulloblastoma Reveal an Oct4/mTOR Axis that Promotes Malignancy.
|
31786016 |
2019 |