|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
We have demonstrated previously that human breast cancer cells regain the ability to express OCT3 mRNA [Jin, Branch, Zhang, Qi, Youngson and Goss (1999) Int.J.Cancer 81, 104-112].
|
12841847 |
2003 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Epigenetic control of CTCFL/BORIS and OCT4 expression in urogenital malignancies.
|
16854382 |
2006 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
A strategy to target "cancer stem cells" is to suppress the Oct-4 gene in order to cause the cells to differentiate.
|
17261754 |
2006 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Oct-3/4 highly expressed in cancer cells may be a potential target for cancer therapy.
|
18281558 |
2008 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
In conclusion, we demonstrated that Oct-4 expression plays a crucial role in maintaining the self-renewing, cancer stem-like, and chemoradioresistant properties of LC-CD133(+).
|
18612434 |
2008 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Cancer stem cell-like cells (CSCLC) are reported to be a minor population in tumors or even in tumor cell lines which also express Oct4.
|
18701476 |
2008 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
GeneChaser displays these conditions in graphs, gives statistical comparisons, allows sort/filter functions and provides access to the original studies.We performed a single gene search for Nanog and a multiple gene search for Nanog, Oct4, Sox2 and LIN28, confirmed their roles in embryonic stem cell development, identified several drugs that regulate their expression, and suggested their potential roles in sex determination, abnormal sperm morphology, malaria infection, and cancer.
|
19094235 |
2008 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Both Oct3/4 and Sox2 were variably expressed in the cancer cell lines, but were either negative or very weakly expressed in the normal cell line.
|
19414369 |
2009 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
The CS12 gastric cell line showed cancer cell phenotypes, i.e. the ability of anchorage-independent growth high frequency (44%) and to the expression of Oct-4, a transcription factor expressed in embryonic stem cells and many types of cancer cells, and tumor development in immune deficient mice.
|
19424076 |
2009 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
These data are consistent with the cancer stem cell model of tumorigenesis in osteosarcoma and implicate a functional link between the capacity to activate an exogenous Oct-4 promoter and tumor formation.
|
19584295 |
2009 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Resistant cell line consisted of a 70% side population fraction enriched with Oct4-positive cancer stem cells.
|
20596658 |
2010 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Although p53 knockout (KO) cells reprogrammed with only Oct4 and Sox2 maintained their pluripotent capacity in vivo, reprogrammed cells expressing mutant p53 lost this capability and gave rise to malignant tumors.
|
20696700 |
2010 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Coexpression of Oct4 and Nanog enhances malignancy in lung adenocarcinoma by inducing cancer stem cell-like properties and epithelial-mesenchymal transdifferentiation.
|
21159654 |
2010 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
The data presented, including SCA-1 and Oct4 positivity and the upregulation of stem cell-like genes such as those associated with the Wnt pathway, support the notion that the macrobead selects for a subpopulation of cells with cancer stem cell or cancer progenitor properties.
|
21266363 |
2011 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Some studies have shown that OCT4 is expressed in adult stem cells, somatic cancers and, further, cancer stem cells, while other studies failed to make such an observation.
|
21341266 |
2011 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Although differentially displayed, the expression of genes related to cancer (BCL-2, p53, NF-κB, TGF-β, VEGF) and transcription and pluripotency (OCT4, NANOG, STAT3, REX1) were commonly observed in MSCs and cancer cells.
|
21638208 |
2011 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Our results provide a valuable dataset for understanding gene regulation mechanisms underlying the function of OCT4 in glioblastoma cancer.
|
21960344 |
2011 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
To investigate whether Oct4, Sox2 and Nanog, three core regulatory factors maintaining pluripotency and self-renewal of embryonic stem cells (ESCs), are coexpressed in human gliomas, and whether their expression might be linked to carcinogenesis and the formation of cancer stem cells (CSCs).
|
22014056 |
2011 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Oct4, a member of the POU-domain transcription factor family, has been implicated in the cancer stem cell (CSC)-like properties of various cancers.
|
22037460 |
2011 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Using OCT4 expression as a marker for the cancer stem cells, the number and size were measured in these cells.
|
22132214 |
2011 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Oct4 is expressed by CSC-like cells in different types of cancer.
|
22286766 |
2012 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Nuclear localization signal-enhanced RNA interference of EZH2 and Oct4 in the eradication of head and neck squamous cell carcinoma-derived cancer stem cells.
|
22361100 |
2012 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
AlteredExpression |
BEFREE |
Using real-time polymerase chain reaction (PCR), Western blotting, immunocytochemistry and immunohistochemistry, the expression of OCT4 in three esophageal squamous cancer cell lines, KYSE70, KYSE140 and KYSE450, was characterized.
|
22363145 |
2012 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Recent studies found that the stem cell-related genes Sox2, Oct4 and Klf4 are among the target genes regulated by microRNA-145 (miR-145), suggesting that miR-145 possibly plays a role in the maintenance of cancer stem cells.
|
22378186 |
2012 |
|
POU5F1P3
|
Malignant Neoplasms
|
0.100 |
Biomarker |
BEFREE |
Stem cell marker LIN28, related closely with SOX2 and OCT4, has been studied as a biomarker for the maintainance of pluripotent cells in several malignancies.
|
22429493 |
2012 |