Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human ACTH hypertension in the rat: role of sodium chloride. 1321011

1992

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Changes in pressor responsiveness do not explain ACTH hypertension. 3015460

1986

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Haemodynamic mechanisms of corticotropin (ACTH)-induced hypertension in the rat. 10658937

1999

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Nitric oxide synthase activity in adrenocorticotrophin-induced hypertension in the rat. 11703388

2001

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human The role of this increased pressor responsiveness in ACTH/steroid-induced hypertension remains to be determined. 1321309

1992

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Adrenocorticotrophin-induced hypertension in rats. Role of progesterone and digoxin-like substances. 8136112

1994

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human However, when RAP is not allowed to rise, ACTH is associated with sodium retention and severe systemic hypertension, suggesting that the natriuretic effects of ACTH are caused by increased RAP and that the natriuresis blunts the chronic hypertensive effects of ACTH. 2849322

1988

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Antioxidant vitamins and adrenocorticotrophic hormone-induced hypertension in rats. 17994356

2007

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human L-arginine partially reverses established adrenocorticotrophin-induced hypertension and nitric oxide deficiency in the rat. 11193135

2000

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human This result indicates that the cardiac glycoside binding site of the alpha1 isoform can also mediate ACTH-induced hypertension. 16243970

2005

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Effects of bromocriptine on blood pressure and plasma beta-endorphin in spontaneously hypertensive rats. 6274577

1981

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Vasodilator prostanoids and ACTH-dependent hypertension. 6135010

1983

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Thus, NAC partially prevented but did not reverse ACTH-induced hypertension. 16546835

2006

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Exaggerated natriuresis in ACTH hypertension in sheep. 216942

1978

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Influence of somatostatin analogue (SMS 201-995, octreotide) on blood pressure in adrenocorticotrophin (ACTH) treated rats: role of hyperinsulinaemia in ACTH hypertension. 8261660

1993

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Effect of sodium depletion on pressor responsiveness in ACTH-induced hypertension in man. 2822310

1987

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Potentiation of ACTH hypertension in man with salt loading. 2992854

1985

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Children who develop hypertension during ACTH therapy should be considered at risk for hypertrophic cardiomyopathy and should undergo routine echocardiographic evaluation. 2821097

1987

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Overall, the data establish that the alpha(2)-Na(+)-K(+)-ATPase ouabain-binding site is of central importance in the development of ACTH-induced hypertension. 18487447

2008

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human These studies suggest that a steroid other than aldosterone, 18-OH-DOC, or DOC may be the cause of the ACTH-induced hypertension in this patient. 187612

1976

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human In man ACTH produces systolic hypertension which can be reproduced by infusion of cortisol, but not deoxycorticosterone, at rates appropriate for conditions of ACTH stimulation. 3001556

1985

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Partial characterization of unusual polar steroids in the urine of a child with low renin hypertension. 6283272

1982

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Atorvastatin prevented and partially reversed adrenocorticotropic hormone-induced hypertension in the rat. 16620303

2006

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Nitric oxide donation lowers blood pressure in adrenocorticotrophic hormone-induced hypertensive rats. 15554453

2004

Entrez Id: 5443
Gene Symbol: POMC
POMC
CUI: C0020538
Disease: Hypertensive disease
Hypertensive disease
0.400 Biomarker CTD_human Role of nitric oxide in adrenocorticotrophin-induced hypertension: L-arginine effects reversed by N-nitro-L-arginine. 11071304

2000