×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
"APC mutations in sporadic colorectal tumors: A mutational ""hotspot"" and interdependence of the ""two hits""."
10737795
2000
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
A genetic progression model of Braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention.
23845441
2013
×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
A single-nucleotide substitution mutator phenotype revealed by exome sequencing of human colon adenomas.
23204322
2012
×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
A unique profile of adenomatous polyposis coli gene mutations in Iranian patients suffering sporadic colorectal cancer.
24518971
2014
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
19794125
2009
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer.
22180495
2012
×
Entrez Id:
3265
Gene Symbol:
HRAS
HRAS
Colorectal Neoplasms
0.200
GeneticVariation
CLINVAR
APC inhibits ERK pathway activation and cellular proliferation induced by RAS.
16478791
2006
×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
APC mutations occur early during colorectal tumorigenesis.
1528264
1992
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Association of KRAS G13D tumor mutations with outcome in patients with metastatic colorectal cancer treated with first-line chemotherapy with or without cetuximab.
22734028
2012
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Association of KRAS p.G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab.
20978259
2010
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
Colorectal Neoplasms
0.410
CausalMutation
CLINVAR
AZD6244 (ARRY-142886), a potent inhibitor of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase 1/2 kinases: mechanism of action in vivo, pharmacokinetic/pharmacodynamic relationship, and potential for combination in preclinical models.
17699718
2007
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF as a target for cancer therapy.
21426297
2011
×
Entrez Id:
4893
Gene Symbol:
NRAS
NRAS
Colorectal Neoplasms
0.410
CausalMutation
CLINVAR
BRAF mutation predicts sensitivity to MEK inhibition.
16273091
2006
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF V600E is a determinant of sensitivity to proteasome inhibitors.
24107445
2013
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF V600E mutation and resistance to anti-EGFR monoclonal antibodies in patients with metastatic colorectal cancer: a meta-analysis.
20857202
2011
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF(V600E) efficient transformation and induction of microsatellite instability versus KRAS(G12V) induction of senescence markers in human colon cancer cells.
19881948
2009
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis.
21716161
2011
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
BRAFV600E mutation and its association with clinicopathological features of colorectal cancer: a systematic review and meta-analysis.
24594804
2014
×
Entrez Id:
5290
Gene Symbol:
PIK3CA
PIK3CA
Colorectal Neoplasms
0.490
CausalMutation
CLINVAR
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
18725974
2008
×
Entrez Id:
5728
Gene Symbol:
PTEN
PTEN
Colorectal Neoplasms
0.160
CausalMutation
CLINVAR
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
18725974
2008
×
Entrez Id:
3845
Gene Symbol:
KRAS
KRAS
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Cetuximab treatment for metastatic colorectal cancer with KRAS p.G13D mutations improves progression-free survival.
26623049
2015
×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
Characteristics of somatic mutation of the adenomatous polyposis coli gene in colorectal tumors.
8187091
1994
×
Entrez Id:
673
Gene Symbol:
BRAF
BRAF
Colorectal Neoplasms
0.500
CausalMutation
CLINVAR
Clinical biomarkers in oncology: focus on colorectal cancer.
19537845
2009
×
Entrez Id:
208
Gene Symbol:
AKT2
AKT2
Colorectal Neoplasms
0.300
GeneticVariation
CLINVAR
Colorectal cancer: mutations in a signalling pathway.
16094359
2005
×
Entrez Id:
324
Gene Symbol:
APC
APC
Colorectal Neoplasms
0.900
GeneticVariation
CLINVAR
Comprehensive molecular characterization of human colon and rectal cancer.
22810696
2012