Source: CLINVAR

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Uncommon epidermal growth factor receptor mutations in non-small cell lung cancer and their mechanisms of EGFR tyrosine kinase inhibitors sensitivity and resistance. 23485129

2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR EGFR somatic doublets in lung cancer are frequent and generally arise from a pair of driver mutations uncommonly seen as singlet mutations: one-third of doublets occur at five pairs of amino acids. 18372921

2008
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR The epidermal growth factor receptor D761Y mutation and effect of tyrosine kinase inhibitor. 17545553

2007
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Therapeutic effect of γ-secretase inhibition in KrasG12V-driven non-small cell lung carcinoma by derepression of DUSP1 and inhibition of ERK. 22897852

2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Prognostic value of the KRAS G12V mutation in 841 surgically resected Caucasian lung adenocarcinoma cases. 26372703

2015
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR High resolution melting analysis of KRAS, BRAF and PIK3CA in KRAS exon 2 wild-type metastatic colorectal cancer. 23548132

2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR PF00299804, an irreversible pan-ERBB inhibitor, is effective in lung cancer models with EGFR and ERBB2 mutations that are resistant to gefitinib. 18089823

2007
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Double mutation and gene copy number of EGFR in gefitinib refractory non-small-cell lung cancer. 16730855

2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Distinct epidermal growth factor receptor and KRAS mutation patterns in non-small cell lung cancer patients with different tobacco exposure and clinicopathologic features. 16533793

2006
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Differential sensitivities to tyrosine kinase inhibitors in NSCLC harboring EGFR mutation and ALK translocation. 22622260

2012
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR The importance of evaluation of DNA amplificability in KRAS mutation testing with dideoxy sequencing using formalin-fixed and paraffin-embedded colorectal cancer tissues. 20926413

2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Erlotinib response in an NSCLC patient with a novel compound G719D+L861R mutation in EGFR. 23945392

2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR A novel EGFR nonsense mutation in a non-small-cell lung cancer (NSCLC) patient who did not derive any clinical benefit with combination chemotherapy and erlotinib. 18628075

2008
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Effect of simvastatin on cetuximab resistance in human colorectal cancer with KRAS mutations. 21398618

2011
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Functional analysis of epidermal growth factor receptor (EGFR) mutations and potential implications for EGFR targeted therapy. 19147750

2009
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. 16187797

2005
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Revisiting clinical trials using EGFR inhibitor-based regimens in patients with advanced non-small cell lung cancer: a retrospective analysis of an MD Anderson Cancer Center phase I population. 23800712

2013
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. 15118073

2004
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Germline KRAS and BRAF mutations in cardio-facio-cutaneous syndrome. 16474404

2006
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Craniosynostosis in patients with Noonan syndrome caused by germline KRAS mutations. 19396835

2009
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma. 20609353

2010
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Prospective enterprise-level molecular genotyping of a cohort of cancer patients. 25157968

2014
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR Mechanisms of resistance to crizotinib in patients with ALK gene rearranged non-small cell lung cancer. 22235099

2012
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR In silico identification of significant detrimental missense mutations of EGFR and their effect with 4-anilinoquinazoline-based drugs. 19455431

2010
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.700 GeneticVariation CLINVAR EGFR mutants found in non-small cell lung cancer show different levels of sensitivity to suppression of Src: implications in targeting therapy. 17653080

2008