×
Entrez Id: 3659
Gene Symbol: IRF1
IRF1
Non-Small Cell Lung Carcinoma
0.120
CausalMutation
CLINVAR
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
"Effectiveness of tyrosine kinase inhibitors on ""uncommon"" epidermal growth factor receptor mutations of unknown clinical significance in non-small cell lung cancer."
21531810 2011
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
"EGF receptor gene mutations are common in lung cancers from ""never smokers"" and are associated with sensitivity of tumors to gefitinib and erlotinib."
15329413 2004
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Non-Small Cell Lung Carcinoma
0.500
CausalMutation
CLINVAR
A novel dual PI3Kalpha/mTOR inhibitor PI-103 with high antitumor activity in non-small cell lung cancer cells.
19513541 2009
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
A novel EGFR nonsense mutation in a non-small-cell lung cancer (NSCLC) patient who did not derive any clinical benefit with combination chemotherapy and erlotinib.
18628075 2008
×
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
Non-Small Cell Lung Carcinoma
0.130
GeneticVariation
CLINVAR
A novel EGFR nonsense mutation in a non-small-cell lung cancer (NSCLC) patient who did not derive any clinical benefit with combination chemotherapy and erlotinib.
18628075 2008
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Non-Small Cell Lung Carcinoma
0.500
CausalMutation
CLINVAR
A structural systems biology approach for quantifying the systemic consequences of missense mutations in proteins.
23093928 2012
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.
20609353 2010
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Non-Small Cell Lung Carcinoma
0.500
GeneticVariation
CLINVAR
Activating BRAF and N-Ras mutations in sporadic primary melanomas: an inverse association with allelic loss on chromosome 9.
14681681 2003
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
GeneticVariation
CLINVAR
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
15118073 2004
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib.
15118073 2004
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Activating mutations in the tyrosine kinase domain of the epidermal growth factor receptor are associated with improved survival in gefitinib-treated chemorefractory lung adenocarcinomas.
16115929 2005
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Activity of epidermal growth factor receptor-tyrosine kinase inhibitors in patients with non-small cell lung cancer harboring rare epidermal growth factor receptor mutations.
21841502 2011
×
Entrez Id: 208
Gene Symbol: AKT2
AKT2
Non-Small Cell Lung Carcinoma
0.460
GeneticVariation
CLINVAR
AKT1 and AKT2 mutations in lung cancer in a Japanese population.
21479466 2012
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Non-Small Cell Lung Carcinoma
0.500
CausalMutation
CLINVAR
Allelic dilution obscures detection of a biologically significant resistance mutation in EGFR-amplified lung cancer.
16906227 2006
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Non-Small Cell Lung Carcinoma
0.500
CausalMutation
CLINVAR
Alterations of BRAF and HIPK2 loci predominate in sporadic pilocytic astrocytoma.
19794125 2009
×
Entrez Id: 1956
Gene Symbol: EGFR
EGFR
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: correlation with clinical outcomes.
21572125 2011
×
Entrez Id: 100507500
Gene Symbol: EGFR-AS1
EGFR-AS1
Non-Small Cell Lung Carcinoma
0.130
CausalMutation
CLINVAR
Assessment of epidermal growth factor receptor and K-ras mutation status in cytological stained smears of non-small cell lung cancer patients: correlation with clinical outcomes.
21572125 2011
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Non-Small Cell Lung Carcinoma
0.500
GeneticVariation
CLINVAR
B-RAF and N-RAS mutations are preserved during short time in vitro propagation and differentially impact prognosis.
17311103 2007
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
BRAF and RAS mutations in human lung cancer and melanoma.
12460918 2002
×
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
Non-Small Cell Lung Carcinoma
0.460
CausalMutation
CLINVAR
BRAF and RAS mutations in human lung cancer and melanoma.
12460918 2002
×
Entrez Id: 4893
Gene Symbol: NRAS
NRAS
Non-Small Cell Lung Carcinoma
0.460
CausalMutation
CLINVAR
BRAF mutations in papillary carcinomas of the thyroid.
14508525 2003
×
Entrez Id: 673
Gene Symbol: BRAF
BRAF
Non-Small Cell Lung Carcinoma
0.500
CausalMutation
CLINVAR
BRAF, p53 and SOX2 in anaplastic thyroid carcinoma: evidence for multistep carcinogenesis.
21716161 2011
×
Entrez Id: 5290
Gene Symbol: PIK3CA
PIK3CA
Non-Small Cell Lung Carcinoma
0.500
CausalMutation
CLINVAR
Breast tumor cells with PI3K mutation or HER2 amplification are selectively addicted to Akt signaling.
18725974 2008
×
Entrez Id: 3845
Gene Symbol: KRAS
KRAS
Non-Small Cell Lung Carcinoma
0.700
CausalMutation
CLINVAR
Cardio-facio-cutaneous and Noonan syndromes due to mutations in the RAS/MAPK signalling pathway: genotype-phenotype relationships and overlap with Costello syndrome.
17704260 2007