Source: CURATED

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0002395
Disease: Alzheimer's Disease
Alzheimer's Disease 		0.680 Biomarker CTD_human

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C1866423
Disease: Quebec platelet disorder
Quebec platelet disorder 		0.670 Biomarker CTD_human

Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C1866423
Disease: Quebec platelet disorder
Quebec platelet disorder 		0.670 Biomarker GENOMICS_ENGLAND QPD is the first bleeding disorder to be associated with a gene duplication event and a PLAU mutation. 20007542

2010
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.510 Biomarker CTD_human Intravenous urokinase in acute myocardial infarction. 3984876

1985
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.510 Biomarker CTD_human Femoral nerve palsy secondary to anticoagulant induced iliacus hematoma. A case report. 2174952

1991
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.510 Biomarker CTD_human Acute myocardial infarction complicating urokinase infusion for total saphenous vein graft occlusion. 8416330

1993
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.510 Biomarker CTD_human Unstable angina or non-Q wave infarction despite long-term aspirin: response to thrombolytic therapy with implications on mechanisms. 2382605

1990
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.510 Biomarker CTD_human [Use of urokinase in acute myocardial infarction]. 3068399

1988
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027051
Disease: Myocardial Infarction
Myocardial Infarction 		0.510 Biomarker CTD_human [The kinetics of plasma coagulation fibrinolysis levels in acute myocardial infarction before and after treatment with intravenous urokinase]. 1908371

1991
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental 		0.500 Biomarker CTD_human Systems level analysis and identification of pathways and networks associated with liver fibrosis. 25380136

2014
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0151699
Disease: Intracranial Hemorrhage
Intracranial Hemorrhage 		0.500 Biomarker CTD_human Low- versus high-dose recombinant urokinase for the treatment of chronic saphenous vein graft occlusion. 10392865

1999
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0151699
Disease: Intracranial Hemorrhage
Intracranial Hemorrhage 		0.500 Biomarker CTD_human Predictors of clinical improvement, angiographic recanalization, and intracranial hemorrhage after intra-arterial thrombolysis for acute ischemic stroke. 10512912

1999
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0151699
Disease: Intracranial Hemorrhage
Intracranial Hemorrhage 		0.500 Biomarker CTD_human Symptomatic intracranial haemorrhage after intra-arterial thrombolysis in acute ischaemic stroke: assessment of 294 patients treated with urokinase. 17308290

2007
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0151699
Disease: Intracranial Hemorrhage
Intracranial Hemorrhage 		0.500 Biomarker CTD_human Intraarterial thrombolysis for treatment of acute stroke: experience in 26 patients with long-term follow-up. 10472989

1999
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0403823
Disease: Asthenozoospermia
Asthenozoospermia 		0.500 Biomarker CTD_human [Correlation of the content and expression of urokinase plasminogen activator with asthenospermia in rat models]. 18998460

2008
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C1527311
Disease: Brain Edema
Brain Edema 		0.500 Biomarker CTD_human Massive cerebral edema after recanalization post-thrombolysis. 11677890

2001
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.400 Biomarker CTD_human Effects of zoledronic acid on proteinase plasma levels in patients with bone metastases. 16475674

2006
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human Matrigel invasion assays with two specific uPA inhibitors, B428 and p-aminobenzamidine, showed that invasion of a prostate cancer cell line containing uPA gene amplification was inhibited by these small-molecule uPA inhibitors, while invasion of prostate cell lines without uPA gene amplification were not. 16430655

2006
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human Is urokinase gene 3'-UTR polymorphism associated with prostate cancer? 17192053

2005
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0376358
Disease: Malignant neoplasm of prostate
Malignant neoplasm of prostate 		0.400 Biomarker CTD_human Matrigel invasion assay showed that prostate cancer cell line PC-3, containing amplification of the uPA gene, was more sensitive to the urokinase inhibitor, amiloride, than DU145 or LNCaP cell lines, which do not have the amplification. 11454671

2001
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0001418
Disease: Adenocarcinoma
Adenocarcinoma 		0.390 Biomarker CTD_human Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 10467400

1999
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.380 Biomarker CTD_human Methylation status of the 32 randomly selected and 16 potential tumor-related genes was analyzed in 10 primary gastric cancers, and 42 genes (ABHD9, ADFP, ALDH1A3, ANXA5, AREG, BDNF, BMP7, CAV1, CDH2, CLDN3, CTSL, EEF1A2, F2R, FADS1, FSD1, FST, FYN, GPR54, GREM1, IGFBP3, IGFBP7, IRS2, KISS1, MARK1, MLF1, MSX1, MTSS1, NT5E, PAX6, PLAGL1, PLAU, PPIC, RBP4, RORA, SCRN1, TBX3, TFAP2C, TNFSF9, ULBP2, WIF1, ZNF177 and ZNF559) were methylated in at least one primary gastric cancer. 16367923

2006
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.370 Biomarker CTD_human Overexpression of urokinase-type plasminogen activator in pancreatic adenocarcinoma is regulated by constitutively activated RelA. 10467400

1999
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.360 Biomarker CTD_human Amplification of the urokinase gene and the sensitivity of prostate cancer cells to urokinase inhibitors. 16430655

2006
Entrez Id: 5328
Gene Symbol: PLAU
PLAU
CUI: C0033578
Disease: Prostatic Neoplasms
Prostatic Neoplasms 		0.360 Biomarker CTD_human Is urokinase gene 3'-UTR polymorphism associated with prostate cancer? 17192053

2005