×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
CTD_human
Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment.
18458677
2009
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
AlteredExpression
BEFREE
Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder .
22832853
2012
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
BEFREE
Some researchers suggested that the elevation of interleukin-6 (IL6 ) correlates with major depression and PTSD.
31291232
2019
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
PSYGENET
Leukocyte telomere length in major depression: correlations with chronicity, inflammation and oxidative stress--preliminary findings.
21448457
2011
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
GeneticVariation
BEFREE
Sex difference in IL-6 modulation of cognition among Chinese individuals with major depressive disorder .
31629608
2019
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
PSYGENET
Tryptophan depletion in depressed patients occurs independent of kynurenine pathway activation.
22683764
2012
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
AlteredExpression
BEFREE
Plasma levels of IL-6 and INF-γ and lipid profile, including total cholesterol (TC), triglycerides (TGs), low-density lipoproteins (LDLs), and high-density lipoproteins, were measured in 60 patients meeting criteria of the fifth version of the Diagnostic and Statistical Manual of Mental Disorders for Major Depression (22 patients who attempted suicide and 38 patients who did not attempt suicide) and 30 healthy controls.
30844329
2019
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
AlteredExpression
BEFREE
A PubMed/Medline database search was performed using the following search terms: sirukumab; anti-IL-6; IL-6 ; major depressive disorder ; inflammation.
27913990
2017
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
GeneticVariation
BEFREE
Interleukin-6 genetic polymorphism and Chinese major depression .
16244501
2005
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
BEFREE
Higher concentration of interleukin 6 - A possible link between major depressive disorder and childhood abuse.
29626828
2018
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
AlteredExpression
BEFREE
Association between increased serum interleukin-6 levels and sustained attention deficits in patients with major depressive disorder .
29415791
2018
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
BEFREE
An altered peripheral IL6 response in major depressive disorder .
26804030
2016
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
AlteredExpression
BEFREE
Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder .
23813968
2013
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
PSYGENET
Reduced expression of glucocorticoid-inducible genes GILZ and SGK-1: high IL-6 levels are associated with reduced hippocampal volumes in major depressive disorder .
22832853
2012
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
AlteredExpression
BEFREE
These gray matter volume differences between bipolar disorder and unipolar depression were negatively correlated with soluble IL-6 receptor levels.
30359810
2019
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
BEFREE
Influence of fluvoxamine on plasma interleukin-6 or clinical improvement in patients with major depressive disorder .
28243095
2017
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
BEFREE
Identification of IL6 as a susceptibility gene for major depressive disorder .
27502736
2016
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
BEFREE
It is concluded that increased production of IL-6 and IL-1 in major depression may underlie both immune activation and the "acute" phase response in that illness, and that disorders in Hp may be related to the pathophysiology and pathogenesis of major depression .
7506108
1994
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
AlteredExpression
BEFREE
The level of IL-6 was associated with sleep disturbances in patients with major depressive disorder .
31417262
2019
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
AlteredExpression
BEFREE
Plasma levels of IL-6 in patients with untreated major depressive disorder : comparison with catecholamine metabolites.
31686824
2019
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
BEFREE
Genetic variation in IL-1β, IL-2, IL-6 , TSPO and BDNF and response to duloxetine or placebo treatment in major depressive disorder .
26556688
2015
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
PSYGENET
Plasma levels of interleukin-6 and selective serotonin reuptake inhibitor response in patients with major depressive disorder .
23813968
2013
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
PSYGENET
We confirmed a similar elevation of serum IL-6 in two separate cohorts of patients with treatment-resistant major depressive disorder .
25331895
2014
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
Biomarker
BEFREE
While cross-sectional associations of inflammatory markers interleukin-6 (IL-6 ) and C-reactive protein with major depressive disorder are well established, evidence for longitudinal associations mostly comes from studies on depression symptoms, not diagnoses.
30819515
2019
×
Entrez Id:
3569
Gene Symbol:
IL6
IL6
Unipolar Depression
0.600
AlteredExpression
BEFREE
The plasma level of IL-6 increased in patients with BD and MD .
28074937
2017