×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
BEFREE
These associations remained significant after excluding HNF1B SNP rs4430796 (a known PCa risk factor) from the analysis.
20203524 2010
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
Biomarker
BEFREE
As in studies from other populations, our findings indicate that HNF1B is also associated with prostate cancer risk in the Korean population.
21982019 2011
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
Large-scale association analysis in Asians identifies new susceptibility loci for prostate cancer.
26443449 2015
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
Genome-wide associations for benign prostatic hyperplasia reveal a genetic correlation with serum levels of PSA.
30410027 2018
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
Multiple newly identified loci associated with prostate cancer susceptibility.
18264097 2008
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.
19767753 2009
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
A large multiethnic genome-wide association study of prostate cancer identifies novel risk variants and substantial ethnic differences.
26034056 2015
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
20676098 2010
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
BEFREE
We identified an endometrial cancer susceptibility locus close to HNF1B at 17q12 (rs4430796 , P = 7.1 × 10(-10)) that is also associated with risk of prostate cancer and is inversely associated with risk of type 2 diabetes.
21499250 2011
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
Biomarker
BEFREE
Some associations appear to be ancestry specific, such as HNF1B , which is associated with prostate cancer in European Americans and Latinos but not in African-Americans.
21459759 2011
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
BEFREE
Genotype TG on 11q13 (rs7931342 , T) could be related to an increased Gleason score, AG on HNF1B (rs4430796 , A) could be associated with PSA increase, and TG on 17q24 (rs1859962 , G) could be negatively associated with an increased BMI in Chinese men with PCa .
23464444 2012
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
PosttranslationalModification
BEFREE
This tumor-suppressor activity is lost when HNF1B is silenced by promoter methylation in the progression to PC .
27732966 2016
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
12 new susceptibility loci for prostate cancer identified by genome-wide association study in Japanese population.
31562322 2019
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
BEFREE
Two studies have identified a version (allele) of a variant in the HNF1B (also known as TCF2 ) gene that predisposes to type 2 diabetes, and one of them showed that the same allele protects men from prostate cancer .
18696045 2008
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
17603485 2007
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
BEFREE
This study demonstrates a complex relationship between variants in the HNF1B region and prostate cancer risk.
21576123 2011
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
BEFREE
The examined HNF1B variants have a highly specific effect on prostate cancer risk with no apparent association with any of the other studied cancer types.
20526366 2010
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
Genome-wide association of familial prostate cancer cases identifies evidence for a rare segregating haplotype at 8q24.21.
27262462 2016
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
AlteredExpression
BEFREE
Expression levels of HNF1B and ECI2 proteins were validated by immunohistochemistry and western blotting at different stages of prostate cancer development.
30655870 2019
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
BEFREE
These findings indicate that the HNF1B variants are directly associated with both diabetes and prostate cancer , that diabetes does not mediate these gene variant-prostate cancer relationships, and the relationship between these diseases is not mediate d through these gene variants.
19998368 2010
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
BEFREE
Two variants on chromosome 17 confer prostate cancer risk, and the one in TCF2 protects against type 2 diabetes.
17603485 2007
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
BEFREE
Meta-analysis of the association between the HNF1B rs4430796 (A>G) polymorphism and risk of prostate cancer based on case-control studies.
26214421 2015
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
Association analyses of more than 140,000 men identify 63 new prostate cancer susceptibility loci.
29892016 2018
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
GWASCAT
Genome-wide association scan for variants associated with early-onset prostate cancer.
24740154 2014
×
Entrez Id: 6928
Gene Symbol: HNF1B
HNF1B
Prostate carcinoma
0.200
GeneticVariation
BEFREE
Evidence for two independent prostate cancer risk-associated loci in the HNF1B gene at 17q12.
18758462 2008