×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Vitamin E protects nerve cells from amyloid beta protein toxicity.
1497677 1992
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Recombinants between the APP gene and the AD locus have been reported which seemed to exclude it as the site of the mutation causing familial AD .
1671712 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease .
1678058 1991
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
12192006 2002
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.
12572668 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease.
12746438 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation.
12852432 2003
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
15590663 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.
15591071 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
15993441 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Peroxisomal proliferation protects from beta-amyloid neurodegeneration.
16204253 2005
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Solution 1H NMR investigation of Zn2+ and Cd2+ binding to amyloid-beta peptide (Abeta) of Alzheimer's disease.
16266835 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Synchrotron-based infrared and X-ray imaging shows focalized accumulation of Cu and Zn co-localized with beta-amyloid deposits in Alzheimer's disease.
16325427 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease.
16492752 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Here, we generated a double homozygous knock-in mouse model that incorporates the Swedish familial Alzheimer's disease mutations and converts mouse Abeta to the human sequence in amyloid precursor protein and had the P264L familial Alzheimer's disease mutation in presenilin-1.
16651627 2006
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
16969627 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Structural studies of the Alzheimer's amyloid precursor protein copper-binding domain reveal how it binds copper ions.
17239395 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
"How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the ""LEARn"" model (latent early-life associated regulation) may explain the triggering of AD."
17430250 2007
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.
18583042 2008
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
beta-Amyloid precursor protein (APP ) mutations cause familial Alzheimer's disease with nearly complete penetrance.19286555 2009
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease.
19818510 2009
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of beta-amyloid toxicity.
20111991 2010
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.
20157255 2010
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study.
20640797 2010
×
Entrez Id: 351
Gene Symbol: APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease.
21157020 2011