×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
"How and when environmental agents and dietary factors affect the course of Alzheimer's disease: the ""LEARn"" model (latent early-life associated regulation) may explain the triggering of AD."
17430250
2007
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
beta-Amyloid precursor protein (APP ) mutations cause familial Alzheimer's disease with nearly complete penetrance.
19286555
2009
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Aβ40 oligomers identified as a potential biomarker for the diagnosis of Alzheimer's disease.
21209907
2010
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Abeta peptides as one of the crucial volume transmission signals in the trophic units and their interactions with homocysteine. Physiological implications and relevance for Alzheimer's disease.
16969627
2007
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Agonists of peroxisome proliferator-activated receptor-gamma attenuate the Abeta-mediated impairment of LTP in the hippocampus in vitro.
15993441
2005
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Amyloid-beta peptide binds with heme to form a peroxidase: relationship to the cytopathologies of Alzheimer's disease.
16492752
2006
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
APP expression, distribution and accumulation are altered by aluminum in a rodent model for Alzheimer's disease.
19818510
2009
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
APP/PS1 transgenic mice treated with aluminum: an update of Alzheimer's disease model.
22507317
2012
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Copper reduction by copper binding proteins and its relation to neurodegenerative diseases.
12572668
2003
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo.
15590663
2005
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Early effects of aluminum chloride on beta-secretase mRNA expression in a neuronal model of beta-amyloid toxicity.
20111991
2010
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Exposure to metal ions regulates mRNA levels of APP and BACE1 in PC12 cells: blockage by curcumin.
18583042
2008
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Here, we generated a double homozygous knock-in mouse model that incorporates the Swedish familial Alzheimer's disease mutations and converts mouse Abeta to the human sequence in amyloid precursor protein and had the P264L familial Alzheimer's disease mutation in presenilin-1.
16651627
2006
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
High performance plasma amyloid-β biomarkers for Alzheimer's disease.
29420472
2018
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Hypothesis for a common basis for neuroprotection in glaucoma and Alzheimer's disease: anti-apoptosis by alpha-2-adrenergic receptor activation.
12852432
2003
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Identification of the key molecules involved in chronic copper exposure-aggravated memory impairment in transgenic mice of Alzheimer's disease using proteomic analysis.
25352456
2015
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Impaired modulation of GABAergic transmission by muscarinic receptors in a mouse transgenic model of Alzheimer's disease.
12746438
2003
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Increasing the predictive accuracy of amyloid-β blood-borne biomarkers in Alzheimer's disease.
21157020
2011
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Inhibition of human high-affinity copper importer Ctr1 orthologous in the nervous system of Drosophila ameliorates Aβ42-induced Alzheimer's disease-like symptoms.
23827522
2013
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Leptin reduces the accumulation of Abeta and phosphorylated tau induced by 27-hydroxycholesterol in rabbit organotypic slices.
20157255
2010
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Metalloenzyme-like activity of Alzheimer's disease beta-amyloid. Cu-dependent catalytic conversion of dopamine, cholesterol, and biological reducing agents to neurotoxic H(2)O(2).
12192006
2002
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Mis-sense mutation Val----Ile in exon 17 of amyloid precursor protein gene in Japanese familial Alzheimer's disease .
1678058
1991
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
On the metal ion (Zn(2+), Cu(2+)) coordination with beta-amyloid peptide: DFT computational study.
20640797
2010
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Oral administration of methysticin improves cognitive deficits in a mouse model of Alzheimer's disease.
28448946
2017
×
Entrez Id:
351
Gene Symbol:
APP
APP
Familial Alzheimer Disease (FAD)
0.400
Biomarker
CTD_human
Oxidation of cholesterol by amyloid precursor protein and beta-amyloid peptide.
15591071
2005