Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0007820
Disease: Cerebrovascular Disorders
Cerebrovascular Disorders 		0.010 Biomarker BEFREE Graphical abstract The specialized treatment strategies of EECP for cardiovascular and cerebrovascular disease. 29713856

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0007847
Disease: Malignant tumor of cervix
Malignant tumor of cervix 		0.010 Biomarker BEFREE This study was conducted to discover novel molecular markers linked with PAUF in cervical cancer using genomic network analysis and to assess their prognostic value in cervical cancer. 30406031

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 AlteredExpression BEFREE Overexpression of PAUF was associated with high-grade tumor (p = 0.014) and chemoresistant tumor (p = 0.017). 30111860

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0302592
Disease: Cervix carcinoma
Cervix carcinoma 		0.010 Biomarker BEFREE This study was conducted to discover novel molecular markers linked with PAUF in cervical cancer using genomic network analysis and to assess their prognostic value in cervical cancer. 30406031

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0677886
Disease: Epithelial ovarian cancer
Epithelial ovarian cancer 		0.010 Biomarker BEFREE We aimed to investigate the possible clinical significance of PAUF in epithelial ovarian cancer. 30111860

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0919267
Disease: ovarian neoplasm
ovarian neoplasm 		0.010 Biomarker BEFREE Recombinant PAUF induced cell activation and proliferation in ovarian cancer cell lines, whereas PAUF knockdown inhibited these properties. 30111860

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C1140680
Disease: Malignant neoplasm of ovary
Malignant neoplasm of ovary 		0.010 Biomarker BEFREE Recombinant PAUF induced cell activation and proliferation in ovarian cancer cell lines, whereas PAUF knockdown inhibited these properties. 30111860

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C2939419
Disease: Secondary Neoplasm
Secondary Neoplasm 		0.010 Biomarker BEFREE We previously showed that PAUF is involved in tumor development and metastases in cervical cancer. 30406031

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C4048328
Disease: cervical cancer
cervical cancer 		0.010 Biomarker BEFREE This study was conducted to discover novel molecular markers linked with PAUF in cervical cancer using genomic network analysis and to assess their prognostic value in cervical cancer. 30406031

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C4721610
Disease: Carcinoma, Ovarian Epithelial
Carcinoma, Ovarian Epithelial 		0.010 Biomarker BEFREE Recombinant PAUF induced cell activation and proliferation in ovarian cancer cell lines, whereas PAUF knockdown inhibited these properties. 30111860

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C1335302
Disease: Pancreatic Ductal Adenocarcinoma
Pancreatic Ductal Adenocarcinoma 		0.010 AlteredExpression BEFREE Pancreatic adenocarcinoma upregulated factor (PAUF) overexpressed in pancreatic ductal adenocarcinoma (PDAC) plays a major role in tumor progression and metastasis by autocrine and paracrine manners. 28988106

2017
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C1832661
Disease: ANOPHTHALMIA AND PULMONARY HYPOPLASIA
ANOPHTHALMIA AND PULMONARY HYPOPLASIA 		0.010 AlteredExpression BEFREE Pancreatic adenocarcinoma upregulated factor (PAUF) overexpressed in pancreatic ductal adenocarcinoma (PDAC) plays a major role in tumor progression and metastasis by autocrine and paracrine manners. 28988106

2017
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0276275
Disease: Disease due to Parvoviridae
Disease due to Parvoviridae 		0.010 Biomarker BEFREE Taken together, these results suggested that PAUF conferred resistance to pancreatic cancer cells against oncolytic parvovirus H-1 infection through IFNAR-mediated signaling. 25727013

2015
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 AlteredExpression BEFREE At the same time, PAUF-siRNA inhibited the invasion, adhesion and migration of the tumor cells. 23677445

2013
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 AlteredExpression BEFREE Here, we demonstrated the presence of PAUF at the intracellular level and its multiple effects on cancer progression. 31095674

2019
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.020 AlteredExpression BEFREE An initial decline of PAUF expression was observed at early stages of colorectal cancer followed by an increase at the metastastic site. 31095674

2019
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 AlteredExpression BEFREE Pancreatic adenocarcinoma upregulated factor (PAUF) overexpressed in pancreatic ductal adenocarcinoma (PDAC) plays a major role in tumor progression and metastasis by autocrine and paracrine manners. 28988106

2017
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.020 GeneticVariation BEFREE The current study provides evidence that the TPST1 rs3757417T>G and PAUF rs12373A>C polymorphisms are possible prognostic biomarkers for patients with colorectal cancer. 25079514

2015
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 AlteredExpression BEFREE Aberrant expression of pancreatic adenocarcinoma upregulated factor (PAUF), a novel secretory protein, has been reported in several types of cancer. 23677445

2013
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression BEFREE Aberrant expression of pancreatic adenocarcinoma upregulated factor (PAUF), a novel secretory protein, has been reported in several types of cancer. 23677445

2013
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker BEFREE The PAUF-mediated increase in cancer cell motility was attenuated by the CXCR4 inhibitor, AMD3100, or by anti-CXCR4 antibody. 19784070

2010
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 Biomarker BEFREE The PAUF-mediated increase in cancer cell motility was attenuated by the CXCR4 inhibitor, AMD3100, or by anti-CXCR4 antibody. 19784070

2010
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 AlteredExpression BEFREE An initial decline of PAUF expression was observed at early stages of colorectal cancer followed by an increase at the metastastic site. 31095674

2019
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 GeneticVariation BEFREE The current study provides evidence that the TPST1 rs3757417T>G and PAUF rs12373A>C polymorphisms are possible prognostic biomarkers for patients with colorectal cancer. 25079514

2015
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 Biomarker BEFREE Further studies demonstrated that PAUF-siRNA inhibited the proliferation of CRC cells, promoted their apoptosis and induced G0/G1 cell cycle arrest. 23677445

2013