Source: ALL

Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C2985280
Disease: Blood Protein Measurement
Blood Protein Measurement 		0.100 GeneticVariation GWASCAT Co-regulatory networks of human serum proteins link genetics to disease. 30072576

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker BEFREE However, underlying molecular mechanism of PAUF functioning in pancreatic cancer are not fully understood yet. 28988106

2017
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker BEFREE Suppression of pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer to gemcitabine and 5FU, and inhibits the formation of pancreatic cancer stem like cells. 29100320

2017
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 Biomarker BEFREE Suppression of pancreatic adenocarcinoma upregulated factor (PAUF) increases the sensitivity of pancreatic cancer to gemcitabine and 5FU, and inhibits the formation of pancreatic cancer stem like cells. 29100320

2017
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 Biomarker BEFREE However, underlying molecular mechanism of PAUF functioning in pancreatic cancer are not fully understood yet. 28988106

2017
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker BEFREE We established a xenograft model of human pancreatic cancer to examine PAUF function in gemcitabine resistance in vivo. 26684804

2016
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 Biomarker BEFREE We established a xenograft model of human pancreatic cancer to examine PAUF function in gemcitabine resistance in vivo. 26684804

2016
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker BEFREE Therefore, PAUF-expressing pancreatic cancer cells could be important targets for oncolytic virus-mediated treatment. 25727013

2015
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 Biomarker BEFREE Therefore, PAUF-expressing pancreatic cancer cells could be important targets for oncolytic virus-mediated treatment. 25727013

2015
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0235974
Disease: Pancreatic carcinoma
Pancreatic carcinoma 		0.050 Biomarker BEFREE Taken together, these results imply that PAUF-targeting TSR can contribute to successful targeted gene therapy for pancreatic cancer. 24189457

2014
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0346647
Disease: Malignant neoplasm of pancreas
Malignant neoplasm of pancreas 		0.050 Biomarker BEFREE Taken together, these results imply that PAUF-targeting TSR can contribute to successful targeted gene therapy for pancreatic cancer. 24189457

2014
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker BEFREE We previously showed that PAUF is involved in tumor development and metastases in cervical cancer. 30406031

2018
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 AlteredExpression BEFREE Pancreatic adenocarcinoma upregulated factor (PAUF) overexpressed in pancreatic ductal adenocarcinoma (PDAC) plays a major role in tumor progression and metastasis by autocrine and paracrine manners. 28988106

2017
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker BEFREE Pancreatic adenocarcinoma upregulated factor (PAUF), a novel oncogene, plays a crucial role in the development of pancreatic cancer, including its metastasis and proliferation. 25727013

2015
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.040 Biomarker BEFREE In this study we show that the soluble protein pancreatic adenocarcinoma upregulated factor (PAUF) has an important role in the metastasis and progression of the disease. 19784070

2010
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 AlteredExpression BEFREE An initial decline of PAUF expression was observed at early stages of colorectal cancer followed by an increase at the metastastic site. 31095674

2019
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 GeneticVariation BEFREE The current study provides evidence that the TPST1 rs3757417T>G and PAUF rs12373A>C polymorphisms are possible prognostic biomarkers for patients with colorectal cancer. 25079514

2015
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.030 Biomarker BEFREE Further studies demonstrated that PAUF-siRNA inhibited the proliferation of CRC cells, promoted their apoptosis and induced G0/G1 cell cycle arrest. 23677445

2013
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 AlteredExpression BEFREE Here, we demonstrated the presence of PAUF at the intracellular level and its multiple effects on cancer progression. 31095674

2019
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.020 AlteredExpression BEFREE An initial decline of PAUF expression was observed at early stages of colorectal cancer followed by an increase at the metastastic site. 31095674

2019
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.020 AlteredExpression BEFREE Pancreatic adenocarcinoma upregulated factor (PAUF) overexpressed in pancreatic ductal adenocarcinoma (PDAC) plays a major role in tumor progression and metastasis by autocrine and paracrine manners. 28988106

2017
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C4722085
Disease: Malignant neoplasm of colon and/or rectum
Malignant neoplasm of colon and/or rectum 		0.020 GeneticVariation BEFREE The current study provides evidence that the TPST1 rs3757417T>G and PAUF rs12373A>C polymorphisms are possible prognostic biomarkers for patients with colorectal cancer. 25079514

2015
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 AlteredExpression BEFREE Aberrant expression of pancreatic adenocarcinoma upregulated factor (PAUF), a novel secretory protein, has been reported in several types of cancer. 23677445

2013
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C1306459
Disease: Primary malignant neoplasm
Primary malignant neoplasm 		0.020 AlteredExpression BEFREE Aberrant expression of pancreatic adenocarcinoma upregulated factor (PAUF), a novel secretory protein, has been reported in several types of cancer. 23677445

2013
Entrez Id: 124220
Gene Symbol: ZG16B
ZG16B
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker BEFREE The PAUF-mediated increase in cancer cell motility was attenuated by the CXCR4 inhibitor, AMD3100, or by anti-CXCR4 antibody. 19784070

2010