Gene Disease Score gda Association Type Original DB Sentence supporting the association PMID PMID Year
Entrez Id: 27185
Gene Symbol: DISC1
DISC1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.800 Biomarker CTD_human DISC1 regulates lactate metabolism in astrocytes: implications for psychiatric disorders. 29643356

2018

Entrez Id: 121278
Gene Symbol: TPH2
TPH2
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.800 Biomarker CTD_human Up-regulation of tryptophan hydroxylase-2 mRNA in the rat brain by chronic fluoxetine treatment correlates with its antidepressant effect. 17950541

2007

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human The association between serotonin transporter gene promoter polymorphism (5-HTTLPR), self-reported symptoms, and dental mercury exposure. 18686203

2008

Entrez Id: 3569
Gene Symbol: IL6
IL6
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. 18458677

2009

Entrez Id: 2908
Gene Symbol: NR3C1
NR3C1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030

2004

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Continuous expression of corticotropin-releasing factor in the central nucleus of the amygdala emulates the dysregulation of the stress and reproductive axes. 18698320

2009

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801. 21945287

2012

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats. 16330021

2006

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Therapeutic CTD_human Increased expression of the Vesicular Glutamate Transporter-1 (VGLUT1) in the prefrontal cortex correlates with differential vulnerability to chronic stress in various mouse strains: effects of fluoxetine and MK-801. 21945287

2012

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Functional polymorphisms in the interleukin-6 and serotonin transporter genes, and depression and fatigue induced by interferon-alpha and ribavirin treatment. 18458677

2009

Entrez Id: 4524
Gene Symbol: MTHFR
MTHFR
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human The authors performed a meta-analysis of studies examining the association between polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR) gene, including MTHFR C677T and A1298C, and common psychiatric disorders, including unipolar depression, anxiety disorders, bipolar disorder, and schizophrenia. 17074966

2007

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Regional serotonin transporter availability and depression are correlated in Wilson's disease. 12898347

2003

Entrez Id: 627
Gene Symbol: BDNF
BDNF
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Therapeutic CTD_human Repeated electroconvulsive stimuli increase brain-derived neurotrophic factor in ACTH-treated rats. 16330021

2006

Entrez Id: 1392
Gene Symbol: CRH
CRH
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Intracerebroventricular corticotropin-releasing factor increases limbic glucose metabolism and has social context-dependent behavioral effects in nonhuman primates. 12438692

2002

Entrez Id: 6532
Gene Symbol: SLC6A4
SLC6A4
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.600 Biomarker CTD_human Estradiol and progesterone modify the effects of the serotonin reuptake transporter polymorphism on serotonergic responsivity to citalopram. 21843009

2011

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.560 Biomarker CTD_human Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role? 17572454

2007

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.560 Biomarker CTD_human Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment. 9729278

1998

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.560 Therapeutic CTD_human Search for biological correlates of depression and mechanisms of action of antidepressant treatment modalities. Do neuropeptides play a role? 17572454

2007

Entrez Id: 4852
Gene Symbol: NPY
NPY
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.560 Therapeutic CTD_human Alterations in neuropeptide Y and Y1 receptor mRNA expression in brains from an animal model of depression: region specific adaptation after fluoxetine treatment. 9729278

1998

Entrez Id: 6281
Gene Symbol: S100A10
S100A10
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.550 Biomarker CTD_human Antidepressant treatment is associated with epigenetic alterations in the promoter of P11 in a genetic model of depression. 21682946

2012

Entrez Id: 5743
Gene Symbol: PTGS2
PTGS2
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.520 Biomarker CTD_human Chronic treatment with celecoxib reverses chronic unpredictable stress-induced depressive-like behavior via reducing cyclooxygenase-2 expression in rat brain. 19356723

2009

Entrez Id: 2260
Gene Symbol: FGFR1
FGFR1
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.510 Biomarker CTD_human We determined the distribution of hippocampal FGF-2 and its receptor (FGFR1) mRNA in post-mortem brains of people who suffered from major depression, bipolar disorder and schizophrenia and those of controls. 16861106

2006

Entrez Id: 5649
Gene Symbol: RELN
RELN
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.500 Biomarker CTD_human Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. 14708030

2004

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.360 Biomarker CTD_human Deficiency in the inhibitory serine-phosphorylation of glycogen synthase kinase-3 increases sensitivity to mood disturbances. 20357757

2010

Entrez Id: 2932
Gene Symbol: GSK3B
GSK3B
CUI: C0041696
Disease: Unipolar Depression
Unipolar Depression
0.360 Biomarker CTD_human A kinesin signaling complex mediates the ability of GSK-3beta to affect mood-associated behaviors. 20534517

2010