×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
A multifactorial likelihood model for MMR gene variant classification incorporating probabilities based on sequence bioinformatics and tumor characteristics: a report from the Colon Cancer Family Registry.
22949379 2013
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Endometrial cancer in four sisters: report of a kindred with presumed cancer family syndrome.
8063241 1994
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Compound heterozygosity for two MSH6 mutations in a patient with early onset of HNPCC-associated cancers, but without hematological malignancy and brain tumor.
16418736 2006
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
The contribution of deleterious germline mutations in BRCA1, BRCA2 and the mismatch repair genes to ovarian cancer in the population.
24728189 2014
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers.
12732731 2003
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
An Ashkenazi founder mutation in the MSH6 gene leading to HNPCC.
19851887 2010
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Major contribution from recurrent alterations and MSH6 mutations in the Danish Lynch syndrome population.
18566915 2009
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Two Swedish founder MSH6 mutations, one nonsense and one missense, conferring high cumulative risk of Lynch syndrome.
16283884 2005
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Characterization of two Ashkenazi Jewish founder mutations in MSH6 gene causing Lynch syndrome.
21155762 2011
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Targeted sequencing of 36 known or putative colorectal cancer susceptibility genes.
28944238 2017
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Risks of Lynch syndrome cancers for MSH6 mutation carriers.
20028993 2010
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer.
17453009 2007
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Germline mutations in a polycytosine repeat of the hMSH6 gene in Korean hereditary nonpolyposis colorectal cancer.
9929971 1999
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Prevalence of alterations in DNA mismatch repair genes in patients with young-onset colorectal cancer.
21056691 2011
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Tumor testing to identify lynch syndrome in two Australian colorectal cancer cohorts.
27273229 2017
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Pathogenic and likely pathogenic variant prevalence among the first 10,000 patients referred for next-generation cancer panel testing.
26681312 2016
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
MSH6 germline mutations are rare in colorectal cancer families.
14520694 2003
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
No association between MUTYH and MSH6 germline mutations in 64 HNPCC patients.
18301448 2008
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
GeneticVariation
CLINVAR
Population-based molecular screening for Lynch syndrome: implications for personalized medicine.
23733757 2013
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Application of a 5-tiered scheme for standardized classification of 2,360 unique mismatch repair gene variants in the InSiGHT locus-specific database.
24362816 2014
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Germ-line msh6 mutations in colorectal cancer families.
10537275 1999
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
MSH6 and PMS2 mutation positive Australian Lynch syndrome families: novel mutations, cancer risk and age of diagnosis of colorectal cancer.
20487569 2010
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Mismatch repair gene mutation spectrum in the Swedish Lynch syndrome population.
27601186 2016
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Mutation analysis of the MLH1, MSH2 and MSH6 genes in patients with double primary cancers of the colorectum and the endometrium: a population-based study in northern Sweden.
14961575 2004
×
Entrez Id: 2956
Gene Symbol: MSH6
MSH6
COLORECTAL CANCER, HEREDITARY NONPOLYPOSIS, TYPE 5
0.700
CausalMutation
CLINVAR
Mutations in 12 genes for inherited ovarian, fallopian tube, and peritoneal carcinoma identified by massively parallel sequencing.
22006311 2011