|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Thus, the PGC-1alpha gene locus influences carbohydrate metabolism and contributes to type 2 diabetes in the population studied.
|
15111510 |
2004 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Together, these results showed that PPARG Pro12Ala and PPARGC1A Gly482Ser variants are associated, alone and in interaction, with insulin and glucose homeostasis and suggest that gene-gene interactions should be taken into account in candidate gene studies of T2DM to identify subjects with markedly different risks of developing the disease.
|
19536736 |
2009 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
We did not find any significant association between three SNPs in the PGC-1alpha gene and T2DM in Hispanics or NHW; however, using FBAT, we found the common Thr612Thr allele of the PGC-1alpha gene to be associated with T2DM among Hispanic subjects carrying the rare Pro12Ala allele of the PPAR-gamma gene (p=.003).
|
17479445 |
2007 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
In conclusion, we suggest that the AA genotype of the Gly482Ser polymorphism of the PGC-1 gene should be considered as a risk factor for the development of type 2 diabetes in Caucasians.
|
15581067 |
2004 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The variant allele of the Gly482Ser polymorphism in peroxisome proliferator-activated receptor-gamma co-activator-1alpha (PPARGC1A or PGC1alpha), a critical determinant of skeletal muscle metabolism, has been associated with obesity and type 2 diabetes.
|
16474966 |
2006 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Genetic studies have suggested that Gly482Ser polymorphism of the PGC-1alpha gene is associated with a higher risk of type 2 diabetes, obesity, and hypertension.
|
18614852 |
2008 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
In a large sample of the Caucasians the rs8192673 of the PGC-1α gene and the rs1801282 of the PPAR-γ gene were associated with waist circumference in subjects with T2DM.
|
25928419 |
2015 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Furthermore, a potential interaction between the Pro12Ala polymorphism of PPAR-gamma2 and the PGC-1 Gly482Ser variant on risk of Type II diabetes was investigated.
|
11793024 |
2001 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
We conclude that the Pro12Pro genotype of the PPAR-gamma2 gene and the 482Ser allele of the PGC-1alpha gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial.
|
15592662 |
2004 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The objective of this case-control study was to explore the relationship between SNPs of PGC-1alpha and type 2 diabetes in the southern Chinese population and to determine whether the common variants: Gly482Ser and Thr394Thr, in the PGC-1alpha gene have any impacts on interaction with myocyte enhancer factor (MEF) 2C.
|
18067759 |
2007 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
We conducted a meta-analysis to assess the association between three polymorphisms (Gly482Ser, Thr394Thr and Thr612Met) in PPARGC1A and T2DM.
|
21294239 |
2011 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The present study provides evidence that a common haplotype of PPARGC1A genetic polymorphisms are moderately associated with T2D in Han Chinese population.
|
19828207 |
2009 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
These data suggest that the PGC-1α Thr394Thr and Gly482Ser polymorphisms are associated with therapeutic efficacy of multiple-dose rosiglitazone in Chinese patients with type 2 diabetes mellitus.
|
20498286 |
2010 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
This study aimed to investigate whether genetic variations in human PPARGC1 gene are associated with metabolic syndrome-related phenotypes and T2D among obese subjects.
|
16122961 |
2006 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
In conclusion, these results indicated that these two variations in the PGC-1alpha gene might not contribute to the risk of hypertension and type 2 diabetes in the Chinese population studied here.
|
15824463 |
2004 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Multivariate model analysis, including T2D status, age, and body mass index (BMI), displayed significant covariance in PPARGC-1α rs8192678; SIRT1 rs7896005; TCF7L2 rs7903146 and rs122243326; UCP3 rs3781907; and HHEX rs1111875 with a P < 0.05.
|
31759989 |
2020 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The objective of the study was to o investigate the relationship of the Gly482Ser (G482S) polymorphism in the peroxisome proliferator-activated receptor gamma coactivator-1alpha (PPARGC1A) gene and type 2 diabetes mellitus (T2DM), obesity, and oxidative status in Chinese adults.
|
19913841 |
2010 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes.
|
24359475 |
2014 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The rs2454206" genes_norm="54790">p.Ile1762Val substitution (TET2-rs2454206) was associated with liver PPARGC1A-methylation and transcriptional levels, and Type 2 diabetes.Our results suggest that 5-hmC might be involved in the pathogenesis of NAFLD by regulating liver mitochondrial biogenesis and PPARGC1A expression.
|
26356709 |
2015 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The present study demonstrates that the AA genotype of the Gly482Ser polymorphism in the PPARGC1 gene might be a risk factor for diabetic retinopathy in the Slovene population (Caucasians) with type 2 diabetes (odds ratio 2.7, 95% confidence interval 1.0-6.8), whereas the Pro12Ala polymorphism of the PPARgamma gene failed to confer susceptibility to diabetic retinopathy.
|
15782399 |
2005 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
There was no strong association between SNPs or haplotypes of PPARGC1A and type 2 diabetes.
|
15937669 |
2005 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The impact of six polymorphisms of PGC-1α with Type 2 Diabetes (T2D) susceptibility was evaluated on 1125 samples comprising of 554 T2D cases and 571 controls among three endogamous groups (Bania, Brahmin and Jat Sikh) of North-West India (Punjab).
|
29063962 |
2018 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
Thermogenic genes expressions in epicardial adipose tissue (UCP1: OR 0.617, 95%CI 0.103-0.989, p=0.042; PGC1α: OR 0.416, 95%CI 0.171-0.912, p=0.031; PRDM16: OR 0.643, 95%CI 0.116-0.997, p=0.044) were showed as protective factors against the presence of heart failure with reduced left ventricular ejection fraction, and age (OR 1.643, 95%CI 1.001-3.143, p=0.026), presence of coronary artery disease (OR 6.743, 95%CI 1.932-15.301, p<0.001) and type-2-diabetes mellitus (OR 4.031, 95%CI 1.099-7.231, p<0.001) were associated as risk factors.
|
28824327 |
2017 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
The significant associations between PGC-1α polymorphisms and T2DM are also discussed in this review.
|
27094040 |
2016 |
|
PPARGC1A
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.600 |
GeneticVariation |
BEFREE |
A single nucleotide variant of the PPARGC1A gene (rs8192678) is associated with T2D susceptibility, relative risk of obesity and insulin resistance, and lower indices of β cell function.
|
29186342 |
2018 |