×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Three germline mutations in the TP53 gene.
9067756 1997
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Comprehensive mutational scanning of the p53 coding region by two-dimensional gene scanning.
9667734 1998
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Childhood adrenocortical carcinoma as a sentinel cancer for detecting families with germline TP53 mutations.
22233476 2012
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A common p53 mutation (R175H) activates c-Met receptor tyrosine kinase to enhance tumor cell invasion.
23792586 2013
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
[Germline tp53 neomutation in a patient with Li-Fraumeni syndrome and pancreatic adenocarcinoma].
16633321 2006
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A patient with 17 primary tumours and a germ line mutation in TP53: tumour induction by adjuvant therapy?
11315715 2000
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
ACMG recommendations for standards for interpretation and reporting of sequence variations: Revisions 2007.
18414213 2008
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Highly prevalent TP53 mutation predisposing to many cancers in the Brazilian population: a case for newborn screening?
19717094 2009
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
A specific linkage between the incidence of TP53 mutations and type of chromosomal translocations in B-precursor acute lymphoblastic leukemia cell lines.
20575032 2010
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Improving performance of multigene panels for genomic analysis of cancer predisposition.
26845104 2016
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
EFGR-mutant lung adenocarcinoma and Li-Fraumeni syndrome: report of two cases and review of the literature.
25433984 2015
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
The p53 isoform, Δ133p53α, stimulates angiogenesis and tumour progression.
22733133 2013
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Early-onset breast cancer patients in the South and Southeast of Brazil should be tested for the TP53 p.R337H mutation.
27223487 2016
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Li-Fraumeni syndrome--a molecular and clinical review.
9218725 1997
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Prevalence and spectrum of germline mutations of the p53 gene among patients with sarcoma.
1565143 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
A detailed study of loss of heterozygosity on chromosome 17 in tumours from Li-Fraumeni patients carrying a mutation to the TP53 gene.
9047394 1997
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Germ-line mutations of the p53 tumor suppressor gene in patients with high risk for cancer inactivate the p53 protein.
1631137 1992
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Germline TP53 mutational spectrum in French Canadians with breast cancer.
25925845 2015
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Prevalence of mutations in a panel of breast cancer susceptibility genes in BRCA1/2-negative patients with early-onset breast cancer.
25503501 2015
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Childhood adrenocortical carcinoma as a sentinel cancer for detecting families with germline TP53 mutations.
22233476 2012
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
DNA binding cooperativity of p53 modulates the decision between cell-cycle arrest and apoptosis.
20471942 2010
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Tetramer formation of tumor suppressor protein p53: Structure, function, and applications.
26572807 2016
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
The Inherited p53 Mutation in the Brazilian Population.
27663983 2016
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
GeneticVariation
CLINVAR
Early onset HER2-positive breast cancer is associated with germline TP53 mutations.
21761402 2012
×
Entrez Id: 7157
Gene Symbol: TP53
TP53
LI-FRAUMENI SYNDROME 1
0.100
CausalMutation
CLINVAR
Understanding the function-structure and function-mutation relationships of p53 tumor suppressor protein by high-resolution missense mutation analysis.
12826609 2003